![conference banner](/images/conference-banner.jpeg)
Abstract
Introduction: A simple and eco-friendly synthesis of novel substituted pyrimido[1,6- a]pyrimidine, pyrimido[1,2-g]purine, and pyrimido[2,1-e]purine was accomplished by refluxing of nucleobases (cytosine, adenine or guanine) and dibenzalacetone (DBA) in water using NaOH as a catalyst.
Methods: The molecular structures of the resulting products were characterized by infrared spectroscopy (FT-IR), mass spectrometry, and proton (1H) and carbon (13C) nuclear magnetic resonance (NMR).
Results: The antibacterial activity of the newly fused heterocycles was assayed against the Gram-positive bacterium Staphylococcus aureus (ATCC 6538) and Gram-negative Escherichia coli (ATCC 8737) using gentamicin as a standard commercially available antibiotic.
Conclusion: In addition, the antioxidant capacity was screened using the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH•) and the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+•) radicals scavenging assay.
Keywords: Pyrimidine, purines, dibenzalacetone, green chemistry, antibacterial activity, antioxidant activity.
[http://dx.doi.org/10.15227/orgsyn.032.0006]
[http://dx.doi.org/10.1039/b703105j] [PMID: 17898894]
[http://dx.doi.org/10.1186/s13065-018-0406-5] [PMID: 29619583]
[http://dx.doi.org/10.1016/S0014-827X(01)01123-5] [PMID: 11718266]
[http://dx.doi.org/10.2174/18715206MTA48MzYzy] [PMID: 32698738]
[http://dx.doi.org/10.3389/fchem.2021.695628] [PMID: 34322475]
[http://dx.doi.org/10.1016/j.ejmech.2004.03.007] [PMID: 15501546]
[http://dx.doi.org/10.1007/s11164-013-1347-1]
[http://dx.doi.org/10.4155/fmc.10.16] [PMID: 21426007]
[http://dx.doi.org/10.1016/j.antiviral.2012.01.007] [PMID: 22306172]
[http://dx.doi.org/10.2174/1573407214666180124160405]
[http://dx.doi.org/10.1016/j.arabjc.2010.12.021]
[http://dx.doi.org/10.1248/cpb.c15-00452] [PMID: 26521851]
[http://dx.doi.org/10.1016/S0014-827X(99)00068-3] [PMID: 10555260]
[http://dx.doi.org/10.1248/cpb.c15-00922] [PMID: 27250790]
[http://dx.doi.org/10.2174/1573406416666191227123048] [PMID: 31880253]
[http://dx.doi.org/10.2174/1568026616666160506145046] [PMID: 27150371]
[http://dx.doi.org/10.1021/jo01030a546]
[http://dx.doi.org/10.1056/NEJM198707233170401] [PMID: 3299089]
[http://dx.doi.org/10.1177/135965359900400101] [PMID: 10682123]
[http://dx.doi.org/10.1002/0471264180.or055.01]
[http://dx.doi.org/10.3762/bjoc.14.137] [PMID: 30013687]
[http://dx.doi.org/10.1002/prac.19933350504]
[http://dx.doi.org/10.1002/cber.19140470133]
[http://dx.doi.org/10.1248/cpb.18.1446]
[http://dx.doi.org/10.1021/ja00333a046]
[http://dx.doi.org/10.1002/zfch.19640040806]
[http://dx.doi.org/10.1248/cpb.36.3253]
[http://dx.doi.org/10.3762/bjoc.15.231] [PMID: 31666873]
[http://dx.doi.org/10.1016/j.tetlet.2010.10.143]
[http://dx.doi.org/10.1039/D1RA05240C] [PMID: 35480240]
[http://dx.doi.org/10.1039/D0SC06000C] [PMID: 34163692]
[http://dx.doi.org/10.21741/9781644900239-3]
[http://dx.doi.org/10.2174/138527209789630514]
[http://dx.doi.org/10.1016/j.cogsc.2019.05.004]
[http://dx.doi.org/10.15227/orgsyn.012.0022]
[http://dx.doi.org/10.1001/archinte.1959.00270080034004] [PMID: 13669774]
[http://dx.doi.org/10.1093/ajcp/45.4_ts.493] [PMID: 5325707]
[http://dx.doi.org/10.1007/BF02873586] [PMID: 11501395]
[http://dx.doi.org/10.1016/S0023-6438(95)80008-5]
[http://dx.doi.org/10.1016/S0891-5849(98)00315-3] [PMID: 10381194]
![Wayfinder Image](/images/wayfinder.jpg)