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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

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Editorial

Targeted Regulation of Intracellular Signal Transduction: A New Paradigm for Stimulation of Neurogenesis in Alzheimer's Disease

Author(s): Gleb Zyuz'kov*

Volume 24, Issue 10, 2023

Published on: 20 July, 2023

Page: [777 - 780] Pages: 4

DOI: 10.2174/1389450124666230719104808

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[1]
Ogbodo JO, Agbo CP, Njoku UO, et al. Alzheimer’s disease: Pathogenesis and therapeutic interventions. Curr Aging Sci 2022; 15(1): 2-25.
[http://dx.doi.org/10.2174/1874609814666210302085232] [PMID: 33653258]
[2]
Zyuz’kov GN, Miroshnichenko LA, Chayikovskyi AV, Kotlovskaya LY. NF-кB: A target for synchronizing the functioning nervous tissue progenitors of different types in Alzheimer’s disease. Curr Mol Pharmacol 2023; 16(2): 234-41.
[http://dx.doi.org/10.2174/1874467215666220601144727] [PMID: 35652396]
[3]
Scheltens P, De Strooper B, Kivipelto M, et al. Alzheimer’s disease. Lancet 2021; 397(10284): 1577-90.
[http://dx.doi.org/10.1016/S0140-6736(20)32205-4] [PMID: 33667416]
[4]
Guzman-Martinez L, Calfío C, Farias GA, Vilches C, Prieto R, Maccioni RB. New frontiers in the prevention, diagnosis, and treatment of alzheimer’s disease. J Alzheimers Dis 2021; 82(s1): S51-63.
[http://dx.doi.org/10.3233/JAD-201059] [PMID: 33523002]
[5]
Zyuz’kov GN. Targeted regulation of intracellular signal transduction in regeneration-competent cells: A new direction for therapy in regenerative medicine. Biointerface Res Appl Chem 2021; 11(4): 12238-51.
[http://dx.doi.org/10.33263/BRIAC114.1223812251]
[6]
Zyuz’kov GN, Miroshnichenko LA, Kotlovskaya LYu, Chayikovskyi AV. Inhibitors of intracellular signaling molecules: New horizons in drug discovery for the treatment of alzheimer’s disease. Biointerface Res Appl Chem 2023; 13: 1-11.
[http://dx.doi.org/10.33263/BRIAC135.401]
[7]
Zyuz’kov GN, Miroshnichenko LA, Polykova TY, Simanina EV. Neuroprotective and neuroregenerative effects of shikonin-mediated inhibition of nf-κb/stat3 in alcoholic encephalopathy. Lett Drug Des Discov 2023; 20(12): 2045-54.
[http://dx.doi.org/10.2174/1570180820666221107112141]
[8]
Zyuz’kov GN, Miroshnichenko LA, Simanina EV, Stavrova LA, Polykova TY. Intracellular signaling molecules of nerve tissue progenitors as pharmacological targets for treatment of ethanol-induced neurodegeneration. J Basic Clin Physiol Pharmacol 2022; 33(3): 305-15.
[http://dx.doi.org/10.1515/jbcpp-2020-0317] [PMID: 33559456]
[9]
Zyuz’kov GN, Miroshnichenko LA, Chaikovsky AV, Kotlovskaya LY. Functional state of various types of regenerative-competent neural tissue cells in β-amyloid-induced neurodegeneration. Bull Exp Biol Med 2022; 173(6): 709-13.
[http://dx.doi.org/10.1007/s10517-022-05617-w] [PMID: 36322306]
[10]
Zyuz’kov GN, Miroshnichenko LA, Polyakova TYu, Stavrova LA, Simanina EV. Prospects for the use of nf-кb inhibitors to stimulate the functions of regeneration: Competent cells of nerve tissue and neuroregeneration in ethanol-induced neurodegeneration. Biointerface Res Appl Chem 2020; 11(1): 8065-74.
[http://dx.doi.org/10.33263/BRIAC111.80658074]
[11]
Zyuz’kov GN, Arkad’evna L, Polykova TY, Simanina EV, Stavrova LA. Targeting cAMP-pathway in regeneration-competent cells of nervous tissue: Potential to create a novel drug for treatment of ethanol-induced neurodegeneration. Cent Nerv Syst Agents Med Chem 2021; 21(3): 172-80.
[http://dx.doi.org/10.2174/1871524921666210907102847] [PMID: 34493198]
[12]
Zyuz’kov G, Miroshnichenko L, Polyakova T, Simanina E. Potential of using JNK and p53 as novel drug targets for the treatment of alcoholic encephalopathy. Indian J Physiol Pharmacol 2022; 66: 233-40.
[http://dx.doi.org/10.25259/IJPP_163_2022]
[13]
Zyuz’kov GN, Miroshnichenko LA, Chaikovsky AV, Kotlovskaya LY. The Role of MARK ERK1/2 and p38 in regulation of functions of neural stem cells and neuroglia under conditions of β-amyloid-induced neurodegeneration. Bull Exp Biol Med 2022; 173(4): 424-8.
[http://dx.doi.org/10.1007/s10517-022-05561-9] [PMID: 36058962]
[14]
Kumar A, Fontana IC, Nordberg A. Reactive astrogliosis: A friend or foe in the pathogenesis of alzheimer’s disease. J Neurochem 2023; 164(3): 309-24.
[http://dx.doi.org/10.1111/jnc.15565] [PMID: 34931315]
[15]
Mangalmurti A, Lukens JR. How neurons die in Alzheimer’s disease: Implications for neuroinflammation. Curr Opin Neurobiol 2022; 75: 102575.
[http://dx.doi.org/10.1016/j.conb.2022.102575] [PMID: 35691251]

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