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Current Drug Research Reviews

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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Review Article

Unveiling Wide Spectrum Therapeutic Implications and Signaling Mechanisms of Valsartan in Diverse Disorders: A Comprehensive Review

Author(s): Kuldeep Kumar, Pooja Rawat, Simrat Kaur, Nirmal Singh*, Harlokesh Narayan Yadav, Dhandeep Singh, Amteshwar Singh Jaggi and Dimple Sethi

Volume 16, Issue 3, 2024

Published on: 22 December, 2023

Page: [268 - 288] Pages: 21

DOI: 10.2174/2589977515666230717120828

Price: $65

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Abstract

Valsartan is an orally active non-peptide angiotensin receptor antagonist, an effective and well-tolerated anti-hypertensive drug. Besides its antihypertensive action, it has clinical implications in many other disorders, like heart failure (HF), arrhythmia, chronic kidney disease (CKD), diabetic complications (DM), atherosclerosis, etc. Besides angiotensin receptor blocking activity, valsartan reduces circulating levels of biochemical markers, such as hs-CRP, which is responsible for its anti-inflammatory and anti-oxidant activity. Moreover, valsartan also acts by inhibiting or inducing various signalling pathways, such as inducing autophagy via the AKT/mTOR/S6K pathway or inhibiting the TLR/NF-kB pathway. The current review exhaustively discusses the therapeutic implications of valsartan with specific emphasis on the mechanism of action in various disorders. The article provides a detailed spectrum of the therapeutic profile of valsartan and will likely be very useful to researchers working in the relevant research areas.

Keywords: Angiotensin-II type-1 receptor, atherosclerosis, chronic kidney disease, diabetes mellitus, valsartan, non-peptide angiotensin receptor.

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