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ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

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Research Article

Alkaloids as Potential Anti-HIV Agents

Author(s): Nidhi Rani*, Randhir Singh*, Praveen Kumar, Prerna Sharma, Rajwinder Kaur, Rashmi Arora and Thakur Gurjeet Singh

Volume 21, Issue 4, 2023

Published on: 31 October, 2023

Page: [240 - 247] Pages: 8

DOI: 10.2174/1570162X21666230608114130

Price: $65

Abstract

Background: Alkaloids are nitrogen-containing compounds that are naturally occurring and have a variety of biological activities, including antimicrobial properties. In this study, the authors used a molecular docking approach to evaluate the anti-HIV potential of 64 alkaloids.

Methods: The authors used the Molegro Virtual Docker software to dock the alkaloids into the active sites of three HIV enzymes: protease, integrase, and non-nucleoside reverse transcriptase (NNRT). The docking scores were used to assess the potential of the alkaloids to inhibit the enzymes.

Results: The results showed the alkaloids to have good potential to inhibit the enzymes. Tubocurarine and reserpine were found to be the most potent alkaloids, with docking scores of -123.776 and - 114.956, respectively.

Conclusion: The authors concluded that tubocurarine and reserpine could be further promoted as potential lead molecules for the development of new anti-HIV drugs.

Keywords: Anti-HIV, integrase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, molecular docking, Molegro Virtual Docker.

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