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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

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Review Article

Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators with Potential Therapeutic Value

Author(s): Jie Shi, Jing Wu, Guizhu Feng, Hailong Yang* and Lixian Mu*

Volume 30, Issue 7, 2023

Published on: 19 June, 2023

Page: [562 - 573] Pages: 12

DOI: 10.2174/0929866530666230525163307

Price: $65

Abstract

Due to the rapid evolution of bacterial drug resistance, anti-infective treatment has become a global problem. Therefore, there is an urgent need to develop alternative treatment strategies. Host defense peptides (HDPs) are important components of the natural immune system and are widely distributed in the animal and plant kingdoms. Amphibians, especially their skin, provide a rich source of natural HDPs encoded by genes. These HDPs exhibit not only broad-spectrum antimicrobial activity but also a wide range of immunoregulatory characteristics, including modulation of antiinflammatory and proinflammatory reactions, regulation of specific cellular functions, enhancement of immune chemotaxis, regulation of adaptive immunity, and promotion of wound healing. They also show potent therapeutic effects on infectious and inflammatory diseases caused by pathogenic microorganisms. Thus, in the current review, we summarize the extensive immunomodulatory functions of natural amphibian HDPs, as well as the challenges of clinical development and potential solutions, which have important implications for the development of new anti-infective drugs.

Keywords: Amphibians, host defense peptides, immunomodulatory functions, clinical application potential, immunomodulators, natural amphibians.

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