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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Phytochemicals and Biological Activities of Pulicaria genus: Emphasis on the Flavonoids and Sesquiterpenoids and Cytotoxicity Effects

Author(s): Marzieh Pourhossein Alamdary and Robabeh Baharfar*

Volume 27, Issue 6, 2023

Published on: 17 July, 2023

Page: [526 - 539] Pages: 14

DOI: 10.2174/1385272827666230522152708

Price: $65

Abstract

The use of herbal remedies is more current in illnesses with chronic diseases. One of these important applications is the usage of many plant-derived compounds as cytotoxic agents for the treatment of cancers. Various research has been done on several species of Pulicaria genus for the evaluation of antihistaminic, antimicrobial, antitumor, antiinflammatory, antioxidant, antibacterial, antifungal, insecticide, and leishmanicidal activities. Some studies have shown that these plants have a rich pool of biometabolites like diterpenes, sesquiterpenes, caryophyllenes, flavonoids, and sesquiterpenoids. The main components in several species of this genus are flavonoids and sesquiterpenoids, which have been identified in chemotaxonomic studies and have shown cytotoxic properties. The Scopus and Science Direct sites were studied to find articles on flavonoid and sesquiterpenoid compounds that have been isolated from the Pulicaria genus.

Several biological compounds were isolated from different species of the Pulicaria genus. The main compounds are flavonoids and sesquiterpenoids, which have different biological effects. Its main effect is cytotoxic effect against several cancer cell lines. This study indicates that the Pulicaria genus has cytotoxic activity but posterity studies are needed to probe the active compounds and their possible expansion as novel anticancer drugs.

Keywords: Pulicaria genus, cytotoxic, flavonoid, sesquiterpenoids, anticancer, cancer.

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