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Abstract
Introduction: We synthesized proline functionalized ionic liquid and further characterized it with analytical techniques.
Method: After getting proper structural information on the above ionic liquid, we utilized them as a catalyst for the asymmetric Mannich-Type Reaction.
Result: We synthesized 6 different types of β-amino α-cyano sulfones derivatives as Mannich adduct using various combinations of different imines and aryl sulphonyl as pre-nucleophiles.
Conclusion: We obtained the corresponding chiral Mannich adduct followed by simple ether washing in excellent yield and stereoselectivity. We recycled the catalyst up to 6 runs without losing the catalytic activity.
Keywords: Proline, organocatalysis, mannich reaction, cyano sulfones, mannich adduct, of β-amino α-cyano, stereoselectivity.
[http://dx.doi.org/10.2174/2213337202666150812230640]
[http://dx.doi.org/10.1155/2014/402860]
[http://dx.doi.org/10.1021/acs.chemrev.6b00156] [PMID: 27463615]
[http://dx.doi.org/10.1038/nature07367] [PMID: 18800128]
[http://dx.doi.org/10.1016/j.molliq.2016.11.123]
[http://dx.doi.org/10.1021/acs.chemrev.7b00246] [PMID: 28535681]
[http://dx.doi.org/10.2174/2213337206666190328210907]
[http://dx.doi.org/10.3390/molecules15031280] [PMID: 20335980]
[http://dx.doi.org/10.2174/221333720503190214105527]
[http://dx.doi.org/10.1039/c1ob05639e] [PMID: 21701727]
[http://dx.doi.org/10.1002/chem.200902747] [PMID: 20235242]
[http://dx.doi.org/10.1002/chin.200311083]
[http://dx.doi.org/10.1002/adsc.200606059]
[http://dx.doi.org/10.1134/S1070428008120154]
[http://dx.doi.org/10.1080/00397911.2020.1811987]
[http://dx.doi.org/10.1039/c3gc40772a]
[http://dx.doi.org/10.2174/221333720602190513074850]
[http://dx.doi.org/10.2174/1570193X1102140609120227]
[http://dx.doi.org/10.1201/9781315148694-2]
[http://dx.doi.org/10.5402/2011/676789] [PMID: 24052829]
[http://dx.doi.org/10.1021/ja9806074]
[http://dx.doi.org/10.1002/anie.198902771]
[http://dx.doi.org/10.1021/jo801968p] [PMID: 19053610]
[http://dx.doi.org/10.1039/c2cc32398b] [PMID: 22662327]
[http://dx.doi.org/10.2174/157017810791824946]
[http://dx.doi.org/10.2174/1570193X1102140609120011]
[http://dx.doi.org/10.2174/1385272823666191204151803]
[http://dx.doi.org/10.2174/1385272819666150825220817]
[http://dx.doi.org/10.1002/anie.200906340] [PMID: 20209543]
[http://dx.doi.org/10.1016/j.tet.2020.130965]
[http://dx.doi.org/10.1002/adsc.200900268]
[http://dx.doi.org/10.1039/C5CC05158D] [PMID: 26223465]
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