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Current Organocatalysis

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ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

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Research Article

Ionic Liquid Supported Organocatalysts for the Asymmetric Mannich- Type Reaction of α-cyano α-sulfonyl Carbanions

Author(s): Vivek Srivastava*

Volume 10, Issue 4, 2023

Published on: 20 July, 2023

Page: [297 - 303] Pages: 7

DOI: 10.2174/2213337210666230516145640

Price: $65

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Abstract

Introduction: We synthesized proline functionalized ionic liquid and further characterized it with analytical techniques.

Method: After getting proper structural information on the above ionic liquid, we utilized them as a catalyst for the asymmetric Mannich-Type Reaction.

Result: We synthesized 6 different types of β-amino α-cyano sulfones derivatives as Mannich adduct using various combinations of different imines and aryl sulphonyl as pre-nucleophiles.

Conclusion: We obtained the corresponding chiral Mannich adduct followed by simple ether washing in excellent yield and stereoselectivity. We recycled the catalyst up to 6 runs without losing the catalytic activity.

Keywords: Proline, organocatalysis, mannich reaction, cyano sulfones, mannich adduct, of β-amino α-cyano, stereoselectivity.

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