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Mini-Review Article

基于microRNA的白血病基因疗法：特性，递送和实验模型

卷 23, 期 4, 2023

发表于: 26 May, 2023

页: [245 - 260] 页: 16

弟呕挨: 10.2174/1566523223666230426153622

价格: $65

摘要

白血病是一种影响白细胞的癌症。在这种疾病中，未成熟的血细胞会发生基因突变，导致与健康细胞相比过度复制并减少细胞死亡。在癌症中，可能存在癌基因的激活和控制某些细胞功能的抑癌基因的失活。尽管传统的癌症治疗对患者的康复有不可否认的贡献，但可能会产生一些不太有益的影响。在这种情况下，基因治疗似乎是经典治疗的替代方案。基因疗法将遗传物质传递给细胞以替换或修改功能失调的基因，这是一种治疗肿瘤的安全方法。基因治疗中探索的核酸类型之一是微小RNA（miRNA），一组内源性、非蛋白质编码、小单链RNA分子，参与基因表达、细胞分裂、分化、血管生成、迁移、凋亡的调节和致癌作用。本综述旨在汇集肿瘤学背景下基于 microRNA 的癌症基因治疗文献中的最新进展，重点关注白血病。

关键词: microRNA，基因治疗，白血病，LMA，LMC，LLA，LLC。

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图形摘要

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