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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Review Article

An Insight on the Prospect of Quinazoline and Quinazolinone Derivatives as Anti-tubercular Agents

Author(s): Namrata Kushwaha, Adarsh Sahu*, Jyotika Mishra, Ankit Soni and Dhawal Dorwal

Volume 20, Issue 8, 2023

Published on: 11 May, 2023

Page: [838 - 869] Pages: 32

DOI: 10.2174/1570179420666230316094435

Price: $65

Abstract

Multiple potential drugs have been developed based on the heterocyclic molecules for the treatment of different symptoms. Among the existing heterocyclic molecules, quinazoline and quinazolinone derivatives have been found to exhibit extensive pharmacological and biological characteristics. One significant property of these molecules is their potency as anti-tubercular agents. Thus, both quinazoline and quinazolinone derivatives are modified using different functional groups as substituents for investigating their anti-tubercular activities. We present a summary of the reported anti-tubercular drugs, designed using quinazoline and quinazolinone derivatives, in this review.

Keywords: Quinazoline, quinazolinone, anti-tubercular activity, SAR, heterocycles, drug.

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