Login Register Cart 0
Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Effectiveness of Aspartame on Insulin, Triglycerides, and Blood Glucose Concentration in Adult Type 2 Diabetic Patients

Author(s): Ammar Salim Ali Deeb*, Maisa Muhammad Amin Al-Qudah, Hashem Ahmad Abu-Harirah, Jafar Muhammad. El-Qudah, Dana Abdelrahim, Hala Mashhour Altaleb and Lana Salman Shoubaki

Volume 20, Issue 2, 2024

Published on: 18 April, 2023

Page: [191 - 197] Pages: 7

DOI: 10.2174/1573401319666230310100116

Price: $65

Abstract

Background: Human beings have an attraction to sweet items: desserts, fruits, honey, etc., which stimulate the sense of taste. However, sweet things tend to have many calories, thus contributing to issues with obesity. Moreover, those with diabetes must strictly limit their consumption of sugar to maintain their blood glucose levels within acceptable limits. Artificial sweeteners contain substances from several distinct chemical classes. The effects of artificial sweeteners on clinically relevant outcomes such as insulin, blood glucose, and lipids have been incompletely studied.

Objective: This study aims to assess the effects of artificial sweeteners on blood glucose, triglycerides, and insulin in healthy, non-diabetic, and diabetic type 2 patients.

Methods: Levels of glucose, triglycerides, and insulin in serum samples from 25 patients with confirmed Diabetic type 2 disease and 30 normal controls were determined at 30, and 60 after the ingestion of the drinks.

Results: Levels of glucose, triglycerides, and insulin were notably higher in patients with diabetic Mellitus compared with the normal group. Both triglycerides and insulin (60 min) were elevated significantly above baseline after the intake of the artificial sweeteners in diabetic patients; however, values for all other conditions across time were very stable.

Conclusion: There is no reason to suppose that a higher consumption would result in an elevation in these measures. Any noted insulin resistance linked to a high intake of artificial sweeteners is likely a function of the excess calories and processed ingredients often included within artificially sweetened food and beverage products.

Keywords: Aspartame, artificial sweeteners, Insulin, triglycerides, blood glucose, DM patients.

« Previous Next »
Graphical Abstract

[1]
Shastry CS, Yatheesh CK, Aswathanarayana BJ. Comparative evaluation of diabetogenic and mutagenic potential of artificial sweeteners-aspartame, acesulfame-K and sucralose. J Health and Allied Sciences NU 2012; 2(3): 80-4.
[http://dx.doi.org/10.1055/s-0040-1709358]
[2]
Harpaz D, Yeo L, Cecchini F, et al. Measuring artificial sweeteners toxicity using a bioluminescent bacterial panel. Molecules 2018; 23(10): 2454.
[http://dx.doi.org/10.3390/molecules23102454] [PMID: 30257473]
[3]
Hu FB. Resolved: There is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes Rev 2013; 14(8): 606-19.
[http://dx.doi.org/10.1111/obr.12040] [PMID: 23763695]
[4]
Bray GA, Popkin BM. Dietary sugar and body weight: Have we reached a crisis in the epidemic of obesity and diabetes?: Health be damned! Pour on the sugar. Diabetes Care 2014; 37(4): 950-6.
[http://dx.doi.org/10.2337/dc13-2085] [PMID: 24652725]
[5]
Al-Mazari IS, Alsarhan A, Amawi KF, et al. Compound expression of inducible nitric oxide synthase (inos) and p53 in prostate tissue of diabetic rats. Gorteria 2021; 61(4)
[6]
Mejia E, Pearlman M. Natural alternative sweeteners and diabetes management. Curr Diab Rep 2019; 19(12): 142.
[http://dx.doi.org/10.1007/s11892-019-1273-8] [PMID: 31754814]
[7]
Sanyaolu A, Marinkovic A, Gosse J, Likaj L, Ayodele O, Okorie C. Artificial sweeteners and their association with Diabetes: A review. J Pub Health Catalog 2019; 1: 1-3.
[8]
Alsunni AA. Effects of artificial sweetener consumption on glucose homeostasis and its association with type 2 diabetes and obesity. Int J Gen Med 2020; 13: 775-85.
[http://dx.doi.org/10.2147/IJGM.S274760] [PMID: 33116769]
[9]
El-Qudah JMF. dietary knowledge among female diabetic patients in amman, Jordan. Curr Res Nutr Food Sci 2016; 4(2)
[http://dx.doi.org/10.12944/CRNFSJ.4.2.04]
[10]
Nagpure S, Mathur K, Agrawal RK, Deshpande D. Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients. J Family Med Prim Care 2020; 9(1): 69-71.
[http://dx.doi.org/10.4103/jfmpc.jfmpc_329_19] [PMID: 32110567]
[11]
Daher MI, Matta JM, Nour AMA. Non-nutritive sweeteners and type 2 diabetes: Should we ring the bell? Diabetes Res Clin Pract 2019; 155: 107786.
[12]
Hanin SA, Priya VV, Gayathri R. Awareness of health effects of aspartame among diabetic patients. Drug Invention Today 2018; 10: 1063-66.
[13]
Al-Qudah MM, Haddad MA, El-Qudah JM. The effects of aqueous ginger extract on Pancrease Histology and on blood glucose in normal and Alloxan monohydrate-induced diabetic rats. Biomed Res 2016; 27(2): 350-6.
[14]
Purohit V, Mishra S. The truth about artificial sweeteners–Are they good for diabetics?. Elsevier 2018; pp. 197-9.
[15]
Fagherazzi G, Vilier A, Sartorelli SD, Lajous M, Balkau B, Clavel-Chapelon F. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale–European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr 2013; 97(3): 517-23.
[http://dx.doi.org/10.3945/ajcn.112.050997] [PMID: 23364017]
[16]
Horwitz DL. Aspartame use by persons with diabetes. In: Aspartame. CRC Press 2020; pp. 633-9.
[17]
Choudhary AK. Aspartame: Should individuals with Type II Diabetes be taking it? Curr Diabetes Rev 2018; 14(4): 350-62.
[http://dx.doi.org/10.2174/1573399813666170601093336] [PMID: 28571543]
[18]
Wilk K, Korytek W, Pelczyńska M, Moszak M, Bogdański P. The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: A review. Nutrients 2022; 14(6): 1261.
[http://dx.doi.org/10.3390/nu14061261] [PMID: 35334918]
[19]
Shelat R, Mehta A, Mor D, Nair S, Parmar K, Gupta M. Scope of natural sweeteners over artificial sweeteners in diabetes mellitus. J Pharm Sci Technol Manag 2020; 4(1)
[20]
von Poser Toigo E, Huffell AP, Mota CS, Bertolini D, Pettenuzzo LF, Dalmaz C. Metabolic and feeding behavior alterations provoked by prenatal exposure to aspartame. Appetite 2015; 87: 168-74.
[http://dx.doi.org/10.1016/j.appet.2014.12.213] [PMID: 25543075]
[21]
Mbambo NP, Dlamini SN, Chukwuma CI, Islam MS. Comparative effects of commonly used commercially available non‐nutritive sweeteners on diabetes‐related parameters in non‐diabetic rats. J Food Biochem 2020; 44(11): e13453.
[http://dx.doi.org/10.1111/jfbc.13453] [PMID: 32869881]
[22]
Miselli MA, Nora ED, Passaro A, Tomasi F, Zuliani G. Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: A longitudinal observational study. Cardiovasc Diabetol 2014; 13(1): 135.
[http://dx.doi.org/10.1186/s12933-014-0135-6] [PMID: 25301574]
[23]
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol 2018; 17(1): 122.
[http://dx.doi.org/10.1186/s12933-018-0762-4] [PMID: 30170598]
[24]
J Bloomer R A Peel S, G Moran R, J MacDonnchadh J. Blood glucose and insulin response to artificially- and sugar-sweetened sodas in healthy men. Integr Food Nutr Metab 2016; 3(1): 268-72.
[http://dx.doi.org/10.15761/IFNM.1000141]
[25]
More TA, Shaikh Z, Ali A. Artificial sweeteners and their health implications: A review. Biosci Biotechnol Res Asia 2021; 18(2): 227-37.
[http://dx.doi.org/10.13005/bbra/2910]

Rights & Permissions Print Cite
Article Metrics
8
2
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy