Pantoprazole-induced Stevens-Johnson Syndrome: A Case-report

Title:Pantoprazole-induced Stevens-Johnson Syndrome: A Case-report

Volume: 19 Issue: 1

Author(s): Mouna Daldoul, Ons Charfi*, Emna Bouattour, Houda Hammami-Ghorbe, Ahmed Zaiem, Samy Fenniche, Ghozlane Lakhoua and Sihem El Aidli

Affiliation:

• National Center of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi, 1006, Tunis, Tunisia
• Faculty of Medicine, University of Tunis El Manar, 15 Rue Djebel Lakhdhar, La Rabta, 1007, Tunis, Tunisia

Keywords: Proton pump inhibitor, pantoprazole, adverse drug reaction, pharmacovigilance, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Abstract:

Introduction: Pantoprazole is a proton pump inhibitor mainly used to treat conditions causing excess stomach acid. Stevens-Johnson syndrome (SJS) is a rare bullous disease. The main etiologic factors are drugs, especially antibiotics, anticonvulsants, oxicam and allopurinol. Proton pump inhibitors have been rarely reported as a causative agent in SJS, and only sporadic cases secondary to pantoprazole have just been mentioned in the literature.

Case Report: A 49-year-old woman was referred to the dermatology department for a pruritic generalized eruption, associated with erosive cheilitis. The patient reported self-medication by pantoprazole for two weeks. Physical examination revealed target-like lesions with bullous center in some areas. A skin detachment on the left breast and the neck affecting 10% of the total body surface area was observed. Mucosal examination revealed erosive, painful cheilitis covered by large hemorrhagic crusts and erosions of the nasal cavity. The lesions cleared completely few days after pantoprazole withdrawal and local corticosteroids. Further investigations ruled out infectious etiologies.

Conclusion: This case highlights the possible occurrence of hypersensitivity reactions due to the use of a PPI, which is a widely used medication and a generally well-tolerated drug.

Cite this article as:

Daldoul Mouna, Charfi Ons*, Bouattour Emna, Hammami-Ghorbe Houda, Zaiem Ahmed, Fenniche Samy, Lakhoua Ghozlane and El Aidli Sihem, Pantoprazole-induced Stevens-Johnson Syndrome: A Case-report, Current Drug Safety 2024; 19 (1) . https://dx.doi.org/10.2174/1574886318666230224092818