Login Register Cart 0
Generic placeholder image

Current Cancer Therapy Reviews

Editor-in-Chief

ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Preventive Effects of Achillea Millefolium, Rosa Damascena and Origanum Majorana Hydroalcoholic Extracts on Breast Cancer in Female Mice

Author(s): Fariba Nabatchian, Mojtaba Ashtiani, Amir Teimourpour, Negin Davoudi, Sara Niknam and Reza Afrisham*

Volume 19, Issue 4, 2023

Published on: 15 March, 2023

Page: [349 - 357] Pages: 9

DOI: 10.2174/1573394719666221228110443

Price: $65

Abstract

Introduction: Breast cancer is overall considered the second most frequently recognized cancer worldwide. Several studies have recently reported the antitumoral properties of some medicinal herbs such as Yarrow (Achillea millefolium), Marjoram (Origanum majorana), and Rose (Rosa damascena Mill L). Therefore, the current study aimed to evaluate the effect of the hydroalcoholic extract of these plants on breast cancer prevention in female mice.

Methods: Mice were classified into five ten=mice groups: normal control (untreated group), tumor group (treated with 4T1 cells), and treatment groups (treated with 4T1 cells+ Yarrow or Rose and Marjoram plants). Then, the levels of cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA), superoxide dismutase (SOD), and total antioxidants were determined. Finally, the tumor size was evaluated.

Results: The hydroalcoholic extract of Yarrow herb significantly decreased the levels of CA-15-3 and CEA (P-value = 0.008 and P-value = 0.018, respectively). In addition, hydroalcoholic extracts of Yarrow, Rose, and Marjoram plants significantly reduced tumor size in comparison with the tumor group (P-value < 0.001 for Yarrow, and P-value = 0.004 for Rose and Marjoram plants). Yarrow herb had the significantly highest effect on tumor size in comparison with Rose and Marjoram plants (P-value = 0.011 for both plants). However, no significant differences were found among the groups treated with the plants in comparison with the tumor mice in terms of SOD and total antioxidants (Pvalue > 0.05).

Conclusion: Our findings revealed that A. millefolium had the greatest antitumor effects on mice with breast cancer in comparison with O. majorana and R. damascena herbs. However, more complementary studies are needed in this regard.

Keywords: Breast cancer, hydroalcoholic extract, herbal medicine, marjoram, rose, yarrow.

« Previous Next »
Graphical Abstract

[1]
Liaudanskas M. Ž vikas V, Petrikaitė V. The potential of dietary antioxidants from a series of plant extracts as anticancer agents against melanoma, glioblastoma, and breast cancer. Antioxidants 2021; 10(7): 1115.
[http://dx.doi.org/10.3390/antiox10071115] [PMID: 34356348]
[2]
Sadegh-Nejadi S, Afrisham R, Emamgholipour S, et al. Influence of plasma circulating exosomes obtained from obese women on tumorigenesis and tamoxifen resistance in MCF = 7 cells. IUBMB Life 2020; 72(9): 1930-40.
[http://dx.doi.org/10.1002/iub.2305] [PMID: 32542981]
[3]
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3(10): 768-80.
[http://dx.doi.org/10.1038/nrc1189] [PMID: 14570043]
[4]
Mouhid L. Improving in vivo efficacy of bioactive molecules: An overview of potentially antitumor phytochemicals and currently available lipid-based delivery systems. J Oncol 2017; 7351976.
[5]
Kotecha R, Takami A, Espinoza JL. Dietary phytochemicals and cancer chemoprevention: A review of the clinical evidence. Oncotarget 2016; 7(32): 52517-29.
[http://dx.doi.org/10.18632/oncotarget.9593] [PMID: 27232756]
[6]
González-Vallinas M, González-Castejón M, Rodríguez-Casado A, Ramírez de Molina A. Dietary phytochemicals in cancer prevention and therapy: A complementary approach with promising perspectives. Nutr Rev 2013; 71(9): 585-99.
[http://dx.doi.org/10.1111/nure.12051] [PMID: 24032363]
[7]
Jokar F. Preparation of etoposide loaded poly butyl cyano acrylate nanoparticles and it’s effect on human brain carcinoma cells BE (2)-C. Pharm Lett 2016; 8(16): 96-100.
[8]
Sajjadiyan SZ. Preparation of silibinin loaded pegylatedniosomal nanoparticles and investigation of its effect on MCF-10A human breast cancer cell line. Pharm Lett 2016; 8(16): 70-5.
[9]
Li Z, Tang Y, Zhu S, et al. Ethanol extract of Patrinia scabiosaefolia induces the death of human renal cell carcinoma 786-O cells via SIRT-1 and mTOR signaling-mediated metabolic disruptions. Oncol Rep 2018; 39(2): 764-72.
[PMID: 29251317]
[10]
Fang L, Zhang Y, Zang Y, et al. HP-1 inhibits the progression of ccRCC and enhances sunitinib therapeutic effects by suppressing EMT. Carbohydr Polym 2019; 223: 115109.
[http://dx.doi.org/10.1016/j.carbpol.2019.115109] [PMID: 31427001]
[11]
Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol 2005; 100(1-2): 72-9.
[http://dx.doi.org/10.1016/j.jep.2005.05.011] [PMID: 16009521]
[12]
Ouyang L, Luo Y, Tian M, et al. Plant natural products: From traditional compounds to new emerging drugs in cancer therapy. Cell Prolif 2014; 47(6): 506-15.
[http://dx.doi.org/10.1111/cpr.12143] [PMID: 25377084]
[13]
Mouhid L, Gómez de Cedrón M, García-Carrascosa E, Reglero G, Fornari T, Ramírez de Molina A. Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer. PLoS One 2019; 14(3): e0214294.
[http://dx.doi.org/10.1371/journal.pone.0214294] [PMID: 30913248]
[14]
Athamneh K, Alneyadi A, Alsamri H, et al. Origanum majorana essential oil triggers p38 MAPK-mediated protective autophagy, apoptosis, and caspase-dependent cleavage of P70S6K in colorectal cancer cells. Biomolecules 2020; 10(3): 412.
[http://dx.doi.org/10.3390/biom10030412] [PMID: 32155920]
[15]
Al-Oqail MM. Oxidative stress mediated cytotoxicity, cell cycle arrest, and apoptosis induced by Rosa damascena in human cervical cancer HeLa cells. Oxidative Medicine and Cellular Longevity 2021.
[http://dx.doi.org/10.1155/2021/6695634]
[16]
Gaweł-Bęben K, Strzępek-Gomółka M, Czop M, Sakipova Z, Głowniak K, Kukula-Koch W. Achillea millefolium L. and Achillea biebersteinii Afan. hydroglycolic extracts–bioactive ingredients for cosmetic use. Molecules 2020; 25(15): 3368.
[http://dx.doi.org/10.3390/molecules25153368] [PMID: 32722270]
[17]
Ali SI, Gopalakrishnan B, Venkatesalu V. Pharmacognosy, phytochemistry and pharmacological properties of Achillea millefolium L.: A review. Phytother Res 2017; 31(8): 1140-61.
[http://dx.doi.org/10.1002/ptr.5840] [PMID: 28618131]
[18]
Pain S, Altobelli C, Boher A, et al. Surface rejuvenating effect of Achillea millefolium extract. Int J Cosmet Sci 2011; 33(6): 535-42.
[http://dx.doi.org/10.1111/j.1468-2494.2011.00667.x] [PMID: 21711463]
[19]
Tadić V, Arsić I, Zvezdanović J, Zugić A, Cvetković D, Pavkov S. The estimation of the traditionally used yarrow (Achillea millefolium L. Asteraceae) oil extracts with anti-inflamatory potential in topical application. J Ethnopharmacol 2017; 199: 138-48.
[http://dx.doi.org/10.1016/j.jep.2017.02.002] [PMID: 28163113]
[20]
Zengin G, Aktumsek A, Ceylan R, et al. Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). Food Funct 2017; 8(3): 1152-65.
[http://dx.doi.org/10.1039/C6FO01847E] [PMID: 28174780]
[21]
Ghobadian Z, Ahmadi M, Rezazadeh L, Hosseini E, Kokhazadeh T, Ghavam S. In vitro evaluation of Achillea millefolium on the production and stimulation of human skin fibroblast cells (HFS-PI-16). Med Arh 2015; 69(4): 212-7.
[http://dx.doi.org/10.5455/medarh.2015.69.212-217] [PMID: 26543303]
[22]
Mohammadhosseini M, Sarker SD, Akbarzadeh A. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. J Ethnopharmacol 2017; 199: 257-315.
[http://dx.doi.org/10.1016/j.jep.2017.02.010] [PMID: 28179115]
[23]
Benhalilou N, Alsamri H, Alneyadi A, et al. Origanum majorana ethanolic extract promotes colorectal cancer cell death by triggering abortive autophagy and activation of the extrinsic apoptotic pathway. Front Oncol 2019; 9: 795.
[http://dx.doi.org/10.3389/fonc.2019.00795] [PMID: 31497536]
[24]
Vasudeva N. Origanum majorana L.-Phyto-pharmacological review. 2015.
[25]
Leeja L, Thoppil JE. Antimicrobial activity of methanol extract of Origanum majorana L. (Sweet marjoram). J Environ Biol 2007; 28(1): 145-6.
[PMID: 17718003]
[26]
Al Dhaheri Y, Eid A, AbuQamar S, et al. Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53. PLoS One 2013; 8(2): e56649.
[http://dx.doi.org/10.1371/journal.pone.0056649] [PMID: 23451065]
[27]
Al Dhaheri Y, Attoub S, Arafat K, et al. Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: Inhibition of NFκB signaling and reduction of nitric oxide production. PLoS One 2013; 8(7): e68808.
[http://dx.doi.org/10.1371/journal.pone.0068808] [PMID: 23874773]
[28]
Yazdanparast R, Shahriyary L. Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascul Pharmacol 2008; 48(1): 32-7.
[http://dx.doi.org/10.1016/j.vph.2007.11.003] [PMID: 18069068]
[29]
Jabbarzadeh Z, Khosh-Khui M. Factors affecting tissue culture of Damask rose (Rosa damascena Mill.). Sci Hortic 2005; 105(4): 475-82.
[http://dx.doi.org/10.1016/j.scienta.2005.02.014]
[30]
Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascena. Iran J Basic Med Sci 2011; 14(4): 295-307.
[PMID: 23493250]
[31]
Awale S. Protective effects of Rosa damascena and its active constituent on Aβ (25-35)-induced neuritic atrophy. Evid-based Complement Altern Med 2011.
[32]
Boskabady MH. Effect of aqueous-ethanolic extract from Rosa damascena on guinea pig isolated heart. Iran J Basic Med Sci 2011; 14(2): 116-21.
[33]
Arezoomandan R, Kazerani HR. The laxative and prokinetic effects of Rosa damascena Mill in rats. Iran J Basic Med Sci 2011; 14(1): 9-16.
[34]
Shafei MN, Rakhshandah H, Boskabady MH. Antitussive effect of Rosa damascena in guinea pigs. Iran J Pharm Res 2010; (4): 231-4.
[35]
Gholamhoseinian A, Fallah H. Sharifi far F. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on α-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine 2009; 16(10): 935-41.
[http://dx.doi.org/10.1016/j.phymed.2009.02.020] [PMID: 19380218]
[36]
Mahmood N, Piacente S, Pizza C, Burke A, Khan AI, Hay AJ. The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena. Biochem Biophys Res Commun 1996; 229(1): 73-9.
[http://dx.doi.org/10.1006/bbrc.1996.1759] [PMID: 8954085]
[37]
Latifi G, Ghannadi A, Minaiyan M. Anti-inflammatory effect of volatile oil and hydroalcoholic extract of Rosa damascena Mill. on acetic acid-induced colitis in rats. Res Pharm Sci 2015; 10(6): 514-22.
[PMID: 26779271]
[38]
Zamiri-Akhlaghi A, Zamiri-Akhlaghi A, Rakhshandeh H, Tayarani-Najaran Z, Mousavi SH. Study of cytotoxic properties of Rosa damascena extract in human cervix carcinoma cell line. Avicenna J Phytomed 2011; 1(2): 74-7.
[39]
Venkatesan B, Subramanian V, Tumala A, Vellaichamy E. Rapid synthesis of biocompatible silver nanoparticles using aqueous extract of Rosa damascena petals and evaluation of their anticancer activity. Asian Pac J Trop Med 2014; 7: S294-300.
[http://dx.doi.org/10.1016/S1995-7645(14)60249-2] [PMID: 25312140]
[40]
Abdel-Hameed ESS, Bazaid SA, Hagag HA. Chemical characterization of Rosa damascena Miller var. trigintipetala Dieck essential oil and its in vitro genotoxic and cytotoxic properties. J Essent Oil Res 2016; 28(2): 121-9.
[http://dx.doi.org/10.1080/10412905.2015.1099120]
[41]
Kumar N, Bhandari P, Singh B, Bari SS. Antioxidant activity and ultra-performance LC-electrospray ionization-quadrupole time-of-flight mass spectrometry for phenolics-based fingerprinting of Rose species: Rosa damascena, Rosa bourboniana and Rosa brunonii. Food Chem Toxicol 2009; 47(2): 361-7.
[http://dx.doi.org/10.1016/j.fct.2008.11.036] [PMID: 19100811]
[42]
Guan X, Bryniarski MA, Morris ME. In vitro and in vivo efficacy of the monocarboxylate transporter 1 inhibitor AR-C155858 in the Murine 4T1 breast cancer tumor model. AAPS J 2019; 21(1): 3.
[http://dx.doi.org/10.1208/s12248-018-0261-2] [PMID: 30397860]
[43]
Cacique AP. Barbosa ÉS, Pinho GP, Silvério FO. Maceration extraction conditions for determining the phenolic compounds and the antioxidant activity of Catharanthus roseus (L.) G. Don. Cienc Agrotec 2020; 44: e017420.
[http://dx.doi.org/10.1590/1413-7054202044017420]
[44]
Mansouri E, Asadi-Samani M, Kooti W, et al. Anti-fertility effect of hydro-alcoholic extract of fennel (Foeniculum vulgare Mill) seed in male Wistar rats. J Vet Res (Pulawy) 2016; 60(3): 357-63.
[http://dx.doi.org/10.1515/jvetres-2016-0052]
[45]
Becherini P, Caffa I, Piacente F, et al. SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice. Cancer Metab 2021; 9(1): 6.
[http://dx.doi.org/10.1186/s40170-021-00240-1] [PMID: 33482921]
[46]
Afrisham R. Inhibitory effect of Heracleum persicum and Ziziphus jujuba on activity of alpha-amylase. J Bot 2015; 2015(1): 1-8.
[http://dx.doi.org/10.1155/2015/824683]
[47]
Ghavami G, Sardari S, Shokrgozar MA. Anticancerous potentials of Achillea species against selected cell lines. J Med Plants Res 2010; 4(22): 2411-7.
[48]
Csupor-Löffler B, Hajdú Z, Zupkó I, et al. Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother Res. 2009; 23(5): 672-6.
[http://dx.doi.org/10.1002/ptr.2697] [PMID: 19107850]
[49]
Vitalini S, Beretta G, Iriti M, et al. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochim Pol 2011; 58(2): 203-9.
[http://dx.doi.org/10.18388/abp.2011_2266] [PMID: 21503279]
[50]
Agar O, Dikmen M, Ozturk N, Yilmaz M, Temel H, Turkmenoglu F. Comparative studies on phenolic composition, antioxidant, wound healing and cytotoxic activities of selected Achillea L. species growing in Turkey. Molecules 2015; 20(10): 17976-8000.
[http://dx.doi.org/10.3390/molecules201017976] [PMID: 26437391]
[51]
Bobis O. Influence of phytochemical profile on antibacterial activity of different medicinal plants against gram-positive and gram-negative bacteria. Appl Biochem Microbiol 2015; 51(1): 113-8.
[http://dx.doi.org/10.1134/S0003683815010044]
[52]
Hagag HA, Bazaid SA, Abdel-Hameed ESS, Salman M. Cytogenetic, cytotoxic and GC-MS studies on concrete and absolute oils from Taif rose, Saudi Arabia. Cytotechnology 2014; 66(6): 913-23.
[http://dx.doi.org/10.1007/s10616-013-9644-5] [PMID: 24101441]
[53]
Zu Y, Yu H, Liang L, et al. Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells. Molecules 2010; 15(5): 3200-10.
[http://dx.doi.org/10.3390/molecules15053200] [PMID: 20657472]
[54]
Hamza RZ, Al-Malki NA, Alharthi S, Alharthy SA, Albogami B, El-Megharbel SM. Chemical characterization of Taif Rose (Rosa damascena) methanolic extract and its physiological effect on liver functions, blood indices, antioxidant capacity, and heart vitality against cadmium chloride toxicity. Antioxidants 2022; 11(7): 1229.
[http://dx.doi.org/10.3390/antiox11071229] [PMID: 35883718]
[55]
Refat MS, Hamza RZ, Adam AMA, et al. Potential therapeutic effects of new ruthenium (III) complex with quercetin: Characterization, structure, gene regulation, and antitumor and anti-inflammatory studies (RuIII/Q novel complex is a potent immunoprotective agent). Crystals 2021; 11(4): 367.
[http://dx.doi.org/10.3390/cryst11040367]

Rights & Permissions Print Cite
Article Metrics
25
3
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy