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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Synthetic Routes to Quinoline-Based Derivatives having Potential Anti-Bacterial and Anti-Fungal Properties

Author(s): Shivangi Sharma and Shivendra Singh*

Volume 26, Issue 15, 2022

Published on: 16 November, 2022

Page: [1453 - 1469] Pages: 17

DOI: 10.2174/1385272827666221021140934

Price: $65

Abstract

Quinoline and its derivatives are part of several natural products. Many of them are active pharmacophores and show enormous biological activities. Owing to their usefulness in drug discovery, we have discussed the plethora of quinoline derivatives showing particularly antibacterial and antifungal activities in this article. Depending upon substitution on the quinoline core, change of functionalities at different positions and change in chain length; unique biological properties are associated with such derivatives of quinolines and in this article, we have delineated the antibacterial and antifungal activities of such activities in detail. In most of the cases, it has been found that substitution at the 5-position leads to enhanced bioactivities. In most cases, 5-halo/5-amino/5-aryl and heteroaryl/5-carbonyl/5-amido show promising antibacterial and antifungal activities. Furthermore, the synthetic aspects of several quinoline derivatives showing antibacterial and antifungal activities are also discussed in this article.

Keywords: Quinoline, antibacterial, antifungal, synthesis, heterocycles, pathogens, minimum inhibitory concentration.

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