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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

Chimeric Antigen Receptor (CAR) T-cell Therapy: A New Genetically Engineered Method of Immunotherapy for Cancer

Author(s): Arun Kumar Singh, Rishabha Malviya*, Amrita Singh, Sonali Sundram and Sudhanshu Mishra

Volume 23, Issue 3, 2023

Published on: 13 October, 2022

Page: [199 - 210] Pages: 12

DOI: 10.2174/1568009622666220928141727

Price: $65

Abstract

Chimeric antigen receptor (CAR T) cell treatment for solid tumours faces significant challenges. CAR T cells are unable to pass the vascular barrier in tumours due to a lack of endothelial leukocyte adhesion molecules. The invasion, activity, and durability of CAR T cells may be hampered by additional immunosuppressive mechanisms present in the solid tumour environment. The use of CAR T cells to attack cancer vascular endothelial metabolic targets from within the blood may simplify the fight against cancer. These are the principles that govern our examination of CAR T cell treatment for tumor cells, with a specific eye toward tumour venous delivery. CAR T cells may also be designed such that they can be readily, safely, and successfully transferred.

Keywords: Solid tumor, angiogenesis, targeted therapy, CAR T cells, blood diffusion, tumour.

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