Abstract
Nuclear factor erythroid 2 (NFE 2) - related factor 2 (NFE2L2 or NRF2) is one of the transcription factors predominantly related to the expression of antioxidant genes. NRF2 plays a pivotal role in controlling redox potential in several tumor characteristics, including cancer cell metabolism, stem-cell-like characteristics, tumor aggressiveness, invasion, and metastasis. Further, it was recently discovered that the noncanonical pathway of NRF2 activation was involved in carcinogenesis. Cancerrelated changes (e.g., metabolic flexibility) that support cancer progression were found to be redox and NRF2 dependent. The pro or antineoplastic effects of NRF2 are essentially based on the specific molecular characteristics of the type of cancer. Therefore, systematic investigation of NRF2 signaling is necessary to clarify its role in cancer etiology. Understanding the role of NRF2 in triggering gene expressions in different types of cancer is quite challenging, which might be useful to target those genes for better clinical outcomes. To decipher the role of NRF2 in tumor formation and progression, largescale genomic and transcriptomic studies are required to correlate the clinical outcomes with the activity of the NRF2 expression system. This review attempts to give insights into the understanding of the role of NRF2 in cancer.
Keywords: NRF2, redox potential, carcinogenesis, gene expression, KEAP 1, cancer.
Current Protein & Peptide Science
Title:Understanding the Role of NRF2 Signalling in Cancer
Volume: 23 Issue: 10
Author(s): Pooja G. Singh, T.S. Gopenath, Kanthesh M. Basalingappa*, Ramesh Bharadwaj MN and R. Ilangovan
Affiliation:
- Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, India
Keywords: NRF2, redox potential, carcinogenesis, gene expression, KEAP 1, cancer.
Abstract: Nuclear factor erythroid 2 (NFE 2) - related factor 2 (NFE2L2 or NRF2) is one of the transcription factors predominantly related to the expression of antioxidant genes. NRF2 plays a pivotal role in controlling redox potential in several tumor characteristics, including cancer cell metabolism, stem-cell-like characteristics, tumor aggressiveness, invasion, and metastasis. Further, it was recently discovered that the noncanonical pathway of NRF2 activation was involved in carcinogenesis. Cancerrelated changes (e.g., metabolic flexibility) that support cancer progression were found to be redox and NRF2 dependent. The pro or antineoplastic effects of NRF2 are essentially based on the specific molecular characteristics of the type of cancer. Therefore, systematic investigation of NRF2 signaling is necessary to clarify its role in cancer etiology. Understanding the role of NRF2 in triggering gene expressions in different types of cancer is quite challenging, which might be useful to target those genes for better clinical outcomes. To decipher the role of NRF2 in tumor formation and progression, largescale genomic and transcriptomic studies are required to correlate the clinical outcomes with the activity of the NRF2 expression system. This review attempts to give insights into the understanding of the role of NRF2 in cancer.
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Cite this article as:
Singh G. Pooja, Gopenath T.S., Basalingappa M. Kanthesh*, MN Bharadwaj Ramesh and Ilangovan R., Understanding the Role of NRF2 Signalling in Cancer, Current Protein & Peptide Science 2022; 23 (10) . https://dx.doi.org/10.2174/1389203723666220914120325
DOI https://dx.doi.org/10.2174/1389203723666220914120325 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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