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Abstract
COVID-19, caused by the SARS-CoV-2 virus, has been expanding. SARS-CoV caused an outbreak in early 2000, while MERS-CoV had a similar expansion of illness in early 2010. Nanotechnology has been employed for nasal delivery of drugs to conquer a variety of challenges that emerge during mucosal administration. The role of nanotechnology is highly relevant to counter this “virus” nano enemy. This technique directs the safe and effective distribution of accessible therapeutic choices using tailored nanocarriers, as well as the interruption of virion assembly, by preventing the early contact of viral spike glycoprotein with host cell surface receptors. This study summarises what we know about earlier SARS-CoV and MERS-CoV illnesses, with the goal of better understanding the recently discovered SARS-CoV-2 virus. It also explains the progress made so far in creating COVID-19 vaccines/ treatments using existing methods. Furthermore, we studied nanotechnology- based vaccinations and therapeutic medications that are now undergoing clinical trials and other alternatives.
Keywords: COVID-19, SARS-CoV-2, MERS-CoV, immune system, nanotechnology, treatment.
[http://dx.doi.org/10.1016/S0140-6736(20)30185-9] [PMID: 31986257]
[http://dx.doi.org/10.1056/NEJMe2001126] [PMID: 31978944]
[http://dx.doi.org/10.1038/s41564-020-0695-z] [PMID: 32123347]
[http://dx.doi.org/10.1016/S0140-6736(20)30260-9] [PMID: 32014114]
[http://dx.doi.org/10.3390/v2081803] [PMID: 21994708]
[http://dx.doi.org/10.1128/JCM.38.12.4523-4526.2000] [PMID: 11101590]
[http://dx.doi.org/10.1086/377612] [PMID: 13130404]
[http://dx.doi.org/10.1128/JCM.43.11.5452-5456.2005] [PMID: 16272469]
[http://dx.doi.org/10.1128/CMR.00102-14] [PMID: 25810418]
[http://dx.doi.org/10.1126/science.1165557] [PMID: 19213880]
[http://dx.doi.org/10.1002/path.1440] [PMID: 12845623]
[http://dx.doi.org/10.3390/pathogens]
[http://dx.doi.org/10.1016/j.cca.2020.05.044] [PMID: 32474009]
[http://dx.doi.org/10.1148/radiol.2020200269] [PMID: 32032497]
[http://dx.doi.org/10.1016/j.tim.2016.03.003] [PMID: 27012512]
[http://dx.doi.org/10.1038/nature05775] [PMID: 17507975]
[http://dx.doi.org/10.1136/bmj.m1375] [PMID: 32241884]
[http://dx.doi.org/10.1056/NEJMc2009316] [PMID: 32283004]
[http://dx.doi.org/10.2807/1560-7917.ES.2020.25.10.2000180] [PMID: 32183930]
[http://dx.doi.org/10.3390/nano10050852] [PMID: 32354113]
[http://dx.doi.org/10.3390/nano10061072]
[http://dx.doi.org/10.3390/nano11123330]
[http://dx.doi.org/10.3390/nano11113002] [PMID: 34835766]
[http://dx.doi.org/10.3390/cancers13143396]
[http://dx.doi.org/10.1073/pnas.0506735102] [PMID: 16169905]
[http://dx.doi.org/10.1002/path.1570] [PMID: 15141377]
[http://dx.doi.org/10.1128/JVI.05300-11] [PMID: 21994442]
[http://dx.doi.org/10.1128/JVI.01815-18] [PMID: 30626688]
[http://dx.doi.org/10.1016/S0140-6736(03)13168-6] [PMID: 12737864]
[http://dx.doi.org/10.1073/pnas.0307140101] [PMID: 14983044]
[http://dx.doi.org/10.1038/nm1280] [PMID: 16116432]
[http://dx.doi.org/10.1177/135965350501000401] [PMID: 16038478]
[http://dx.doi.org/10.1016/j.jddst.2021.102988]
[http://dx.doi.org/10.1038/sj.cr.7290286] [PMID: 15780182]
[http://dx.doi.org/10.1016/j.antiviral.2004.09.005] [PMID: 15652970]
[http://dx.doi.org/10.1016/j.bbrc.2004.09.180] [PMID: 15504339]
[http://dx.doi.org/10.1177/135965350400900310] [PMID: 15259899]
[http://dx.doi.org/10.1128/JVI.78.14.7523-7527.2004] [PMID: 15220426]
[http://dx.doi.org/10.1016/S0014-5793(04)00087-0] [PMID: 14988013]
[http://dx.doi.org/10.1038/sj.gt.3302479] [PMID: 15772689]
[http://dx.doi.org/10.1371/journal.pmed.0030237] [PMID: 16796401]
[http://dx.doi.org/10.1128/JVI.79.10.5900-5906.2005] [PMID: 15857975]
[http://dx.doi.org/10.1073/pnas.0701000104] [PMID: 17620608]
[http://dx.doi.org/10.1001/jama.289.21.JOC30885] [PMID: 12734147]
[http://dx.doi.org/10.7326/0003-4819-141-9-200411020-00006] [PMID: 15520422]
[http://dx.doi.org/10.1016/S0140-6736(03)13412-5] [PMID: 12781535]
[http://dx.doi.org/10.3201/eid1001.030553] [PMID: 15078593]
[http://dx.doi.org/10.1016/j.vaccine.2005.08.105] [PMID: 16213065]
[http://dx.doi.org/10.4049/jimmunol.172.9.5194] [PMID: 15100256]
[http://dx.doi.org/10.1016/j.cell.2006.02.019] [PMID: 16497593]
[http://dx.doi.org/10.1073/pnas.0600287103] [PMID: 16505353]
[http://dx.doi.org/10.1056/NEJMoa1211721] [PMID: 23075143]
[PMID: 24827411]
[http://dx.doi.org/10.2807/ese.18.24.20503-en] [PMID: 23787162]
[http://dx.doi.org/10.1016/S1473-3099(13)70154-3] [PMID: 23782859]
[http://dx.doi.org/10.2807/ese.18.24.20502-en] [PMID: 23787161]
[PMID: 23517868]
[http://dx.doi.org/10.2807/1560-7917.ES2014.19.16.20782] [PMID: 24786258]
[http://dx.doi.org/10.1128/JVI.01244-13] [PMID: 23678167]
[http://dx.doi.org/10.1038/nature12005] [PMID: 23486063]
[http://dx.doi.org/10.1128/JVI.00161-14] [PMID: 24554656]
[http://dx.doi.org/10.1073/pnas.1407087111] [PMID: 25288733]
[http://dx.doi.org/10.1016/j.epidem.2014.09.011] [PMID: 25480133]
[http://dx.doi.org/10.1080/02652048.2022.2051625] [PMID: 35282781]
[http://dx.doi.org/10.1111/1469-0691.12562] [PMID: 24460984]
[http://dx.doi.org/10.1016/j.ijid.2014.09.003] [PMID: 25303830]
[http://dx.doi.org/10.1016/S1473-3099(14)70793-5] [PMID: 24964934]
[http://dx.doi.org/10.1016/S0140-6736(13)60982-4] [PMID: 23727167]
[http://dx.doi.org/10.7326/M13-2486] [PMID: 24474051]
[http://dx.doi.org/10.2807/1560-7917.ES2013.18.36.20574] [PMID: 24079378]
[http://dx.doi.org/10.3201/eid2008.140590] [PMID: 25062254]
[http://dx.doi.org/10.3201/eid2008.140596] [PMID: 25075637]
[http://dx.doi.org/10.1016/S1473-3099(13)70164-6] [PMID: 23933067]
[http://dx.doi.org/10.1128/mBio.00884-14] [PMID: 24570370]
[http://dx.doi.org/10.3201/eid2007.140571] [PMID: 24964193]
[http://dx.doi.org/10.3201/eid2012.141026] [PMID: 25425139]
[http://dx.doi.org/10.1111/tbed.12212] [PMID: 24456414]
[http://dx.doi.org/10.3201/eid2004.131746] [PMID: 24655412]
[http://dx.doi.org/10.1128/JVI.03445-14] [PMID: 25653445]
[http://dx.doi.org/10.1038/nmicrobiol.2016.226] [PMID: 27892925]
[http://dx.doi.org/10.1056/NEJMoa2001017] [PMID: 31978945]
[http://dx.doi.org/10.1007/s11427-020-1637-5] [PMID: 32009228]
[http://dx.doi.org/10.1002/jmv.25682] [PMID: 31967321]
[http://dx.doi.org/10.1038/s41586-020-2169-0] [PMID: 32218527]
[http://dx.doi.org/10.1016/j.cell.2020.02.058] [PMID: 32155444]
[http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.2020033273]
[http://dx.doi.org/10.1038/s41564-020-0688-y] [PMID: 32094589]
[http://dx.doi.org/10.26508/lsa.202000786] [PMID: 32703818]
[http://dx.doi.org/10.1183/13993003.00688-2020] [PMID: 32269089]
[http://dx.doi.org/10.1093/cvr/cvaa078] [PMID: 32227090]
[http://dx.doi.org/10.1056/NEJMc2001468] [PMID: 32003551]
[http://dx.doi.org/10.1016/j.jhin.2020.06.001] [PMID: 32360355]
[http://dx.doi.org/10.1056/NEJMc2004973] [PMID: 32182409]
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]
[http://dx.doi.org/10.1016/S1473-3099(20)30086-4] [PMID: 32105637]
[http://dx.doi.org/10.1056/NEJMc2005073] [PMID: 32187458]
[http://dx.doi.org/10.1016/S1473-3099(20)30198-5] [PMID: 32220650]
[http://dx.doi.org/10.1016/S0140-6736(20)30566-3] [PMID: 32171076]
[http://dx.doi.org/10.1016/j.cell.2020.04.026] [PMID: 32416070]
[http://dx.doi.org/10.3389/fmicb.2020.01800] [PMID: 32793182]
[http://dx.doi.org/10.1111/ijcp.13525] [PMID: 32374903]
[http://dx.doi.org/10.1101/2020.06.20.161323]
[http://dx.doi.org/10.1038/s41422-020-0282-0] [PMID: 32020029]
[http://dx.doi.org/10.1016/j.antiviral.2020.104786] [PMID: 32251767]
[http://dx.doi.org/10.1056/NEJMoa2007016] [PMID: 32275812]
[http://dx.doi.org/10.1016/S0140-6736(20)31022-9] [PMID: 32423584]
[http://dx.doi.org/10.1093/cid/ciaa237] [PMID: 32150618]
[http://dx.doi.org/10.3785/j.issn.1008-9292.2020.03.03]
[http://dx.doi.org/10.1001/jamanetworkopen.2020.8857] [PMID: 32330277]
[http://dx.doi.org/10.1136/thorax.2003.012658] [PMID: 14985565]
[http://dx.doi.org/10.1038/s41423-020-0374-2] [PMID: 32047258]
[http://dx.doi.org/10.1016/j.cell.2020.04.031] [PMID: 32375025]
[http://dx.doi.org/10.1038/s41467-020-16256-y] [PMID: 32366817]
[http://dx.doi.org/10.1038/s41586-020-2349-y] [PMID: 32422645]
[http://dx.doi.org/10.2217/imt-2016-0020] [PMID: 27381687]
[http://dx.doi.org/10.1038/s41584-020-0372-x] [PMID: 32034323]
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105955] [PMID: 32234468]
[http://dx.doi.org/10.1038/s41586-020-2012-7] [PMID: 32015507]
[http://dx.doi.org/10.1001/jama.2020.4783] [PMID: 32219428]
[http://dx.doi.org/10.1126/science.abb2507] [PMID: 32075877]
[http://dx.doi.org/10.1038/s41591-020-0820-9] [PMID: 32284615]
[http://dx.doi.org/10.1002/jmv.25688] [PMID: 31994738]
[http://dx.doi.org/10.1016/bs.aivir.2016.08.003] [PMID: 27712626]
[http://dx.doi.org/10.3390/v11010059] [PMID: 30646565]
[http://dx.doi.org/10.1038/s41586-020-2294-9] [PMID: 32365353]
[http://dx.doi.org/10.1016/j.chom.2020.04.004] [PMID: 32289263]
[http://dx.doi.org/10.1007/s40475-020-00201-6] [PMID: 32219057]
[http://dx.doi.org/10.1371/journal.pcbi.1006857] [PMID: 31323032]
[http://dx.doi.org/10.1038/d41573-020-00073-5] [PMID: 32273591]
[http://dx.doi.org/10.2174/1567201815666180716112457] [PMID: 30009708]
[http://dx.doi.org/10.2174/1568005033481123] [PMID: 14529359]
[http://dx.doi.org/10.1016/j.vaccine.2013.04.050] [PMID: 23664987]
[http://dx.doi.org/10.1038/35046108] [PMID: 11117750]
[http://dx.doi.org/10.1038/415331a] [PMID: 11797011]
[http://dx.doi.org/10.1089/10430340260355347] [PMID: 12427305]
[http://dx.doi.org/10.1093/hmg/ddr141] [PMID: 21531790]
[http://dx.doi.org/10.1038/sj.gt.3302233] [PMID: 15042119]
[http://dx.doi.org/10.1038/sj.gt.3301109] [PMID: 10680012]
[http://dx.doi.org/10.2174/1566523054064968] [PMID: 15975007]
[http://dx.doi.org/10.1182/blood-2010-08-302729] [PMID: 21106988]
[http://dx.doi.org/10.1016/S0140-6736(20)31604-4] [PMID: 32702298]
[http://dx.doi.org/10.1038/nrg3763] [PMID: 25022906]
[http://dx.doi.org/10.1038/gt.2016.79] [PMID: 27874854]
[http://dx.doi.org/10.3389/fcimb.2013.00013] [PMID: 23532930]
[http://dx.doi.org/10.1016/S0169-409X(02)00228-4] [PMID: 12628320]
[http://dx.doi.org/10.1039/C7MD00158D] [PMID: 30108916]
[http://dx.doi.org/10.1007/s11705-018-1729-4]
[http://dx.doi.org/10.1016/j.bbrc.2015.08.023] [PMID: 26260323]
[http://dx.doi.org/10.1166/jbn.2016.2157] [PMID: 27280242]
[http://dx.doi.org/10.1016/j.nantod.2020.101051] [PMID: 33519949]
[http://dx.doi.org/10.1186/1741-7015-10-104] [PMID: 22973873]
[http://dx.doi.org/10.1109/TNANO.2016.2516561]
[http://dx.doi.org/10.1074/jbc.M112.437202] [PMID: 23362274]
[http://dx.doi.org/10.1371/journal.pmed.1001997] [PMID: 27093560]
[http://dx.doi.org/10.1007/s11095-005-7147-6] [PMID: 16132350]
[http://dx.doi.org/10.1097/QAI.0b013e3182a99590] [PMID: 24169120]
[http://dx.doi.org/10.1093/cid/ciy540] [PMID: 30184165]
[http://dx.doi.org/10.1371/journal.pone.0024095] [PMID: 21935377]
[http://dx.doi.org/10.1016/B978-0-12-391858-1.00001-0] [PMID: 22568898]
[http://dx.doi.org/10.1016/j.ijpharm.2012.12.031] [PMID: 23279938]
[http://dx.doi.org/10.4238/2014.March.19.2] [PMID: 24682984]
[PMID: 18203424]
[http://dx.doi.org/10.2174/1567201815666180604110457]
[http://dx.doi.org/10.1002/hep.28025] [PMID: 26239691]
[http://dx.doi.org/10.1111/apt.13707] [PMID: 27375283]
[http://dx.doi.org/10.1056/NEJMoa020681] [PMID: 12606735]
[PMID: 18516259]
[PMID: 29179600]
[http://dx.doi.org/10.3748/wjg.v21.i44.12558] [PMID: 26640332]
[http://dx.doi.org/10.3390/molecules200814051] [PMID: 26247927]
[http://dx.doi.org/10.1371/journal.pone.0141050] [PMID: 26474396]
[http://dx.doi.org/10.1038/s41565-020-0752-z] [PMID: 32747742]
[http://dx.doi.org/10.2174/0929867326666190827151741] [PMID: 31453778]
[http://dx.doi.org/10.1016/j.ijpharm.2007.03.025] [PMID: 17475423]
[http://dx.doi.org/10.1080/03639045.2019.1583758] [PMID: 30767591]
[http://dx.doi.org/10.3109/10717544.2014.920431] [PMID: 24901207]
[http://dx.doi.org/10.1016/j.jsps.2015.02.014] [PMID: 27013909]
[http://dx.doi.org/10.2147/IJN.S68861] [PMID: 25678787]
[http://dx.doi.org/10.1016/S0304-4165(02)00528-7]
[http://dx.doi.org/10.1111/j.1750-3841.2011.02580.x] [PMID: 22329855]
[http://dx.doi.org/10.1016/j.preteyeres.2016.12.001] [PMID: 28028001]
[http://dx.doi.org/10.1021/acs.chemrev.5b00046] [PMID: 26010257]
[http://dx.doi.org/10.1023/A:1018916518515] [PMID: 8290471]
[http://dx.doi.org/10.1016/0009-3084(93)90053-6] [PMID: 8242840]
[http://dx.doi.org/10.1023/A:1020134521778] [PMID: 12428901]
[http://dx.doi.org/10.1038/s41598-018-32033-w] [PMID: 30228359]
[http://dx.doi.org/10.7150/thno.9404] [PMID: 25057313]
[http://dx.doi.org/10.1038/nature08956]
[http://dx.doi.org/10.2174/2468187312666211222123307]
[http://dx.doi.org/10.1056/NEJMoa1716153] [PMID: 29972753]
[http://dx.doi.org/10.1021/mp200572t] [PMID: 22462641]
[http://dx.doi.org/10.1021/mp200264m] [PMID: 22149016]
[http://dx.doi.org/10.1038/s41467-017-02390-7] [PMID: 29255160]
[http://dx.doi.org/10.1126/scitranslmed.aad2355] [PMID: 26865565]
[http://dx.doi.org/10.1007/s12272-018-1008-4] [PMID: 29450862]
[http://dx.doi.org/10.1039/C3RA47370H]
[http://dx.doi.org/10.1016/j.xphs.2018.07.013]
[http://dx.doi.org/10.1007/s11095-008-9800-3] [PMID: 19107579]
[http://dx.doi.org/10.1016/j.progpolymsci.2011.01.001]
[http://dx.doi.org/10.1038/nrd4333] [PMID: 25287120]
[http://dx.doi.org/10.1021/ja210844h] [PMID: 22320198]
[http://dx.doi.org/10.1038/nbt1171] [PMID: 16333296]
[PMID: 18717480]
[http://dx.doi.org/10.1177/0883911505053377]
[http://dx.doi.org/10.1042/BST0350061] [PMID: 17233602]
[http://dx.doi.org/10.1517/17425240902735806] [PMID: 19239390]
[http://dx.doi.org/10.3389/fbioe.2019.00261] [PMID: 31709243]
[http://dx.doi.org/10.1586/14760584.2015.1064772] [PMID: 26152550]
[http://dx.doi.org/10.3389/fimmu.2017.00239] [PMID: 28337198]
[http://dx.doi.org/10.1038/mt.2014.30] [PMID: 24599278]
[http://dx.doi.org/10.2217/17435889.3.4.555] [PMID: 18694317]
[http://dx.doi.org/10.1016/j.nantod.2015.06.006] [PMID: 26640510]
[http://dx.doi.org/10.1116/1.2815690] [PMID: 20419892]
[http://dx.doi.org/10.1039/D0NA00472C]
[http://dx.doi.org/10.1016/j.jbiotec.2019.10.007] [PMID: 31614169]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.01.073] [PMID: 29343454]
[http://dx.doi.org/10.1128/JVI.01615-07] [PMID: 18032492]
[http://dx.doi.org/10.1371/journal.pone.0190868] [PMID: 29324805]
[http://dx.doi.org/10.1016/j.jbiotec.2011.04.011] [PMID: 21536082]
[http://dx.doi.org/10.1073/pnas.1510533112] [PMID: 26392546]
[http://dx.doi.org/10.1002/bit.21716] [PMID: 18023052]
[http://dx.doi.org/10.1021/nn201397z] [PMID: 21615170]
[http://dx.doi.org/10.1021/nn502043d] [PMID: 25073013]
[http://dx.doi.org/10.1371/journal.pone.0120751] [PMID: 25830365]
[http://dx.doi.org/10.1021/bc100367u] [PMID: 21355575]
[http://dx.doi.org/10.3389/fimmu.2020.01100] [PMID: 32582186]
[http://dx.doi.org/10.1038/nbt.3037] [PMID: 25362245]
[http://dx.doi.org/10.1038/nnano.2013.54] [PMID: 23584215]
[http://dx.doi.org/10.1038/s41586-020-2066-6] [PMID: 32132711]
[http://dx.doi.org/10.1073/pnas.1505799112] [PMID: 26504197]
[http://dx.doi.org/10.1126/science.aau0810] [PMID: 32079747]
[http://dx.doi.org/10.1002/adma.201705350] [PMID: 29280210]
[http://dx.doi.org/10.1073/pnas.2014352117] [PMID: 33024017]
[http://dx.doi.org/10.1021/acs.nanolett.0c02278] [PMID: 32551679]
[http://dx.doi.org/10.1007/s12257-019-0170-y]
[http://dx.doi.org/10.1016/j.virol.2006.12.011] [PMID: 17258782]
[http://dx.doi.org/10.1681/ASN.2009111156] [PMID: 20558536]
[http://dx.doi.org/10.1007/s10517-009-0647-3] [PMID: 19902110]
[http://dx.doi.org/10.1681/ASN.2008070798] [PMID: 19389847]
[http://dx.doi.org/10.1016/S0301-472X(02)00791-9] [PMID: 12031651]
[http://dx.doi.org/10.1016/S0014-4827(03)00055-7] [PMID: 12706119]
[http://dx.doi.org/10.2302/kjm.53.210] [PMID: 15647627]
[http://dx.doi.org/10.1016/S0092-8674(03)00513-0] [PMID: 12859896]
[http://dx.doi.org/10.1158/1535-7163.MCT-05-0102] [PMID: 16227410]
[PMID: 12907600]
[http://dx.doi.org/10.22159/ijap.2020v12i4.36856]
[http://dx.doi.org/10.1016/j.nano.2015.03.009] [PMID: 25839392]
[http://dx.doi.org/10.1016/S1473-3099(18)30292-5] [PMID: 29914800]
[http://dx.doi.org/10.1056/NEJMoa013552] [PMID: 12167680]
[http://dx.doi.org/10.1007/s11481-006-9032-4] [PMID: 18040810]
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