Abstract
Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and electronics is well established. As a result, the synthesis of quinoline core and its derivatives have been an attractive goal for the synthetic organic chemist. In the recent past there have been several new developments in the chemistry associated with quinolines. In pursuit to develop easy and practical approaches to a variety of quinoline derivatives decorated with useful pharmacophores different research workers have made use of new catalysts, medium or physical conditions in several well established synthetic methodologies. Besides an array of new and innovative strategies from novel substrates have been developed which has rendered the synthesis of quinoline core a much simpler process as compared earlier. An assimilation of the literature related to the advances in the syntheses of quinolines and quinoline-annulated ring systems since 2005 is being presented here.
Keywords: Synthesis, Quinoline, heterocyclic scaffold, medicine, quinoline-annulated ring systems, pharmacophores
Current Organic Chemistry
Title: Advances in the Syntheses of Quinoline and Quinoline-Annulated Ring Systems
Volume: 12 Issue: 13
Author(s): Sudharshan Madapa, Zehra Tusi and Sanjay Batra
Affiliation:
Keywords: Synthesis, Quinoline, heterocyclic scaffold, medicine, quinoline-annulated ring systems, pharmacophores
Abstract: Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and electronics is well established. As a result, the synthesis of quinoline core and its derivatives have been an attractive goal for the synthetic organic chemist. In the recent past there have been several new developments in the chemistry associated with quinolines. In pursuit to develop easy and practical approaches to a variety of quinoline derivatives decorated with useful pharmacophores different research workers have made use of new catalysts, medium or physical conditions in several well established synthetic methodologies. Besides an array of new and innovative strategies from novel substrates have been developed which has rendered the synthesis of quinoline core a much simpler process as compared earlier. An assimilation of the literature related to the advances in the syntheses of quinolines and quinoline-annulated ring systems since 2005 is being presented here.
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Cite this article as:
Madapa Sudharshan, Tusi Zehra and Batra Sanjay, Advances in the Syntheses of Quinoline and Quinoline-Annulated Ring Systems, Current Organic Chemistry 2008; 12 (13) . https://dx.doi.org/10.2174/138527208785740300
DOI https://dx.doi.org/10.2174/138527208785740300 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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