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摘要
慢性高血糖损害神经和血管,最终引起其他血管并发症。这些并发症会增强细胞因子、氧化和内质网(ER)应激。ER是蛋白质合成的主要细胞器,并在其目的地之前发生确定变化。ER稳态的扰乱激活了其腔内的信号传感器,即协调ER应激的被广泛研究的未折叠蛋白反应(未折蛋白反应,UPR)。据报道,在糖尿病并发症中,ER应激标志物增加,而长链非编码RNA是诱导ER应激反应的上游标志物。本文就长链非编码RNA(IncRNA)调控ER应激标志物,特别是在糖尿病并发症进展中的作用机制进行综述。通过这一系统性综述,我们展示了作为糖尿病并发症进展中引起ER应激反应的主要原因的功能失调的长链非编码RNA。
关键词: 长链非编码RNA,内质网应激,糖尿病并发症,胰岛素分泌,内质网应激反应,非折叠蛋白反应
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