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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

Chemistry of 2-Aminoquinolines: Synthesis, Reactivity, and Biological Activities

Author(s): Moustafa A. Gouda* and Ghada G. El-Bana*

Volume 20, Issue 5, 2023

Published on: 27 August, 2022

Page: [509 - 529] Pages: 21

DOI: 10.2174/1570193X19666220629103027

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Abstract

This review described the preparation of 2-chloroquinoline-3-carbaldehyde derivatives through Vilsmeier-Haack formylation of N-arylacetamides and their use as a key intermediate for the preparation of 2-aminoquinoline-3-carbaldehydes. The synthesis of the 2-aminoquinolines can be done through the following chemical reactions: Claisen-Schmidt condensation, 1, 3-dipolar cycloaddition, one-pot multicomponent reactions (MCRs), and reductive amination.

Keywords: 2-chloroquinoline-3-carbaldehyde, 2-aminoquinoline-3-carbaldehydes, Vilsmeier-Haack, synthesis, reactivity, reductive animation.

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