Aminopeptidases in Cancer, Biology and Prospects for Pharmacological
Intervention

doi:10.2174/1568009622666220623112605
摘要

氨基肽酶催化蛋白质氨基末端氨基酸的裂解，广泛分布于自然界，在细胞代谢、信号转导、血管生成和免疫等过程和功能中起着至关重要的作用。它们还参与细胞增殖所需的氨基酸和蛋白质的内稳态。肿瘤细胞的生存高度依赖于外源性氨基酸的供应，氨基肽酶的过表达促进了肿瘤细胞的快速增殖。此外，临床研究表明，氨基肽酶高表达的癌症患者往往预后较差。新出现的证据支持抑制氨基肽酶活性作为新治疗方案的靶向方法的基本原理，因为限制氨基酸的可用性可能对肿瘤细胞有选择性地致命。虽然有直接靶向氨基肽酶的药物显示出作为癌症治疗的潜力，如苯丁抑制素和托塞司他，但还需要更有选择性和更有针对性的治疗方法。这篇文章专门研究了氨基肽酶在正常和癌症过程中的生物学作用，以及它们作为未来治疗策略的生物靶点的潜力。当检查以前的出版物时，大多数没有涉及氨基肽酶及其在癌症过程中的作用。氨基肽酶在细胞过程和功能中起着至关重要的作用;然而，它们的过表达可能导致肿瘤细胞的快速增殖。新出现的证据支持利用氨基肽酶活性作为新的肿瘤治疗的靶向方法的基本原理。这篇文章专门研究了氨基肽酶在正常和癌症过程中的生物学作用，以及它们作为未来治疗策略的生物靶点的潜力。
关键词: 癌症，肽酶，氨基酸，肽酶抑制剂，肽药物偶联物，代谢，血管生成，未折叠蛋白反应。
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图形摘要

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DOI https://dx.doi.org/10.2174/1568009622666220623112605	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
当代肿瘤药物靶点

癌症中的氨基肽酶，生物学和药理干预展望

摘要

图形摘要

Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy

Innovative Cancer Drug Targets: A New Horizon in Oncology

ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT

Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment

当代肿瘤药物靶点

癌症中的氨基肽酶，生物学和药理干预展望

摘要

图形摘要

Call for Papers in Thematic Issues

Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy

Innovative Cancer Drug Targets: A New Horizon in Oncology

ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT

Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment

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