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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Review Article

Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction

Author(s): Vandana Kamath, Mary Purna Chacko and Mohan S. Kamath*

Volume 23, Issue 5, 2022

Published on: 05 July, 2022

Page: [326 - 336] Pages: 11

DOI: 10.2174/1389202923666220518095758

Price: $65


In the decade since non-invasive prenatal testing (NIPT) was first implemented as a prenatal screening tool, it has gained recognition for its sensitivity and specificity in the detection of common aneuploidies. This review mainly focuses on the emerging role of NIPT in pregnancies following assisted reproductive technology (ART) in the light of current evidence and recommendations. It also deals with the challenges, shortcomings and interpretational difficulties related to NIPT in ART pregnancies, with particular emphasis on twin and vanishing twin pregnancies, which are widely regarded as the Achilles’ heel of most pre-natal screening platforms. Future directions for exploration towards improving the performance and extending the scope of NIPT are also addressed.

Keywords: NIPT, prenatal screening, aneuploidy, ART, pregnancy, assisted reproduction, non-invasive.

Graphical Abstract
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