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Cardiovascular & Hematological Agents in Medicinal Chemistry

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ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

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Research Article

Study of the Antihypertensive Effect of Laurus nobilis in Rats

Author(s): Ismail Bouadid, Ayoub Amssayef and Mohamed Eddouks*

Volume 21, Issue 1, 2023

Published on: 07 September, 2022

Page: [42 - 54] Pages: 13

DOI: 10.2174/1871525720666220512154041

Price: $65

Abstract

Aims: The study aimed to study the antihypertensive activity of Laurus nobilis.

Background: Laurus nobilis L. is used to treat hypertension in Morocco.

Objective: The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.

Materials and Methods: The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.

Results: A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.

Conclusion: The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.

Keywords: Laurus nobilis, medicinal plant, hypertension, blood pressure, vasorelaxant activity, ACE-2.

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