Title:Biological Activities and Therapeutic Potential of Irigenin on Gastric,
Lung, Prostate, Breast, and Endometrial Cancer: Pharmacological and
Analytical Aspects
Volume: 18
Issue: 3
Author(s): Dinesh Kumar Patel*
Affiliation:
- Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Faculty of Health Sciences,
Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, Uttar Pradesh, India
Keywords:
Irigenin, gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation, cardiac injury.
Abstract:
Background: Herbal medicines have been used for thousands of years due to their pharmacological
activities against different types of human disorders. The biological effectiveness and
pharmacological activities of herbal medicines are mainly due to the presence of different kinds of
phytoconstituents, commonly called secondary metabolites. Isoflavones are naturally present in
different types of plants and food materials, and most of these phytocompounds have a wide range of
biological activities, including anti-tumor, anti-proliferative, anti-inflammatory, anti-microbial, antiviral,
anti-oxidant, and estrogen-like activities.
Methods: Irigenin isolated from the rhizome of Belamcanda chinensis and the genus Iris showed a
wide range of biological activities. Due to the huge biological potential and the therapeutic benefits
of irigenin in medicine, here in the present investigation, scientific research data on irigenin has been
collected from different literature sources (Science Direct, Google Scholar, PubMed, Google) and
analyzed in order to know the therapeutic potential of irigenin in medicine. Scientific data on the
pharmacological activities of irigenin have been collected from Science Direct, Google Scholar,
PubMed, and Google databases and analyzed in the present work. The importance of different analytical
techniques for the isolation and separation of irigenin has also been discussed and presented
in the current work.
Results: Scientific data analysis of different research works revealed the biological importance of
irigenin in medicine. Irigenin is an O-methylated isoflavone found to be present in the Belamcanda
chinensis and genus Iris. Scientific data analysis revealed the biological importance of irigenin
against gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic
complications, inflammation, and cardiac injury. Analytical data on irigenin revealed the importance
of analytical techniques for the separation, isolation, and identification of irigenin from various
biological samples.
Conclusion: Scientific data analysis of different research works revealed the biological importance
and therapeutic potential of irigenin in medicine.