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Recent Advances in Anti-Infective Drug Discovery

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ISSN (Print): 2772-4344
ISSN (Online): 2772-4352

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Mini-Review Article

Herbal Phytomedicine ‘Irisolidone’ in Chronic Diseases: Biological Efficacy and Pharmacological Activity

Author(s): Dinesh Kumar Patel*

Volume 17, Issue 1, 2022

Published on: 20 May, 2022

Page: [13 - 22] Pages: 10

DOI: 10.2174/1574891X16666220304231934

Price: $65

Abstract

Background: Plant-derived products have been used in medicine as a source of bioactive molecules, mainly due to their medicinal importance and therapeutic potential. Nowadays, plant derived products have been used in the medicine for the development of novel drug leads. Polyphenols are an important class of secondary metabolites found to be present in plants and their derived products. Polyphenols play an important role in the nutrition of human beings and also have a significant role in plant resistance against pests and diseases. Scientific studies have proven the biological importance of flavonoids in medicine and other allied health sectors. Anti-oxidant, analgesic, anti-microbial, anti-inflammatory, anti-viral, anti-tumor and anti-allergic activities are the important pharmacological features of flavonoids. Irisolidone is an important isoflavone found to be present in Pueraria lobata flowers.

Methods: To know the medicinal importance and therapeutic potential of irisolidone in the medicine, numerous scientific research data have been collected from Google, Google Scholar, PubMed, Science Direct, and Scopus. Pharmacological activity data of irisolidone has been collected and analyzed in the present works to know their health beneficial aspects in the medicine. Detailed pharmacological activities of irisolidone have been investigated through scientific data analysis of scientific research works.

Results: Scientific research data analysis of irisolidone revealed the anti-inflammatory, antiangiogenic, anti-cancer, anti-platelet, anti-oxidant, anti-hyperlipidemic, immunomodulating, hepatoprotective and estrogenic potential. However, the biological effect of irisolidone on the gastric system, aldose reductase enzymes, malignant gliomas, and JC virus has also been investigated. Scientific data analysis revealed the significance of analytical tools for the separation and identification of irisolidone.

Conclusion: Present work signified the biological importance and therapeutic potential of irisolidone in medicine.

Keywords: Anti-inflammatory, anti-cancer, anti-platelet, antioxidant, antiallergic, immunomodulating, irisolidone.

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[1]
Alara OR, Abdurahman NH, Olalere OA. Ethanolic extraction of flavonoids, phenolics and antioxidants from Vernonia amygdalina leaf using two-level factorial design. J King Saud Univ Sci 2020; 32: 7-16.
[http://dx.doi.org/10.1016/j.jksus.2017.08.001]
[2]
Pereira SV, Reis RASP, Garbuio DC, de Freitas LAP. Dynamic maceration of Matricaria chamomilla inflorescences: Optimal conditions for flavonoids and antioxidant activity. Rev Bras Farmacogn 2018; 28: 111-7.
[http://dx.doi.org/10.1016/j.bjp.2017.11.006]
[3]
Rehman MN, Ahmad M, Sultana S, Zafar M, Edwards S. Relative popularity level of medicinal plants in Talagang, Punjab Province, Pakistan. Rev Bras Farmacogn 2017; 27: 751-75.
[http://dx.doi.org/10.1016/j.bjp.2017.09.004]
[4]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. Rhamnazin: A systematic review on ethnopharmacology, pharma-cology and analytical aspects of an important phytomedicine. Curr Tradit Med 2018; 4: 120-7.
[http://dx.doi.org/10.2174/2215083804666180416124949]
[5]
Dzoyem JP, Tchamgoue J, Tchouankeu JC, Kouam SF, Choudhary MI, Bakowsky U. Antibacterial activity and cyto-toxicity of flavonoids compounds isolated from Pseudarthria hookeri Wight & Arn. (Fabaceae). S Afr J Bot 2018; 114: 100-3.
[http://dx.doi.org/10.1016/j.sajb.2017.11.001]
[6]
Patel K, Kumar V, Verma A, Rahman M, Patel DK. β-sitosterol: Bioactive compounds in foods, their role in health pro-motion and disease prevention “A Concise Report of its Phytopharmaceutical Importance.”. Curr Tradit Med 2017; 3: 168-77.
[http://dx.doi.org/10.2174/2215083803666170615111759]
[7]
Li N, Zhang P, Wu H, Wang J, Liu F, Wang W. Natural flavonoids function as chemopreventive agents from Gancao (Glycyrrhiza inflata Batal). J Funct Foods 2015; 19: 563-74.
[http://dx.doi.org/10.1016/j.jff.2015.09.045]
[8]
Coelho PLC, de Freitas SRV-B, Pitanga BPS, da Silva VDA, Oliveira MN, Grangeiro MS. Flavonoids from the Brazilian plant Croton betulaster inhibit the growth of human glioblastoma cells and induce apoptosis. Rev Bras Farmacogn 2016; 26: 34-43.
[http://dx.doi.org/10.1016/j.bjp.2015.05.013]
[9]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. New insights into the medicinal importance, physiological functions and bioanalytical aspects of an important bioactive compound of foods ‘Hyperin’: Health benefits of the past, the pre-sent, the future. Beni Suef Univ J Basic Appl Sci 2018; 7: 31-42.
[http://dx.doi.org/10.1016/j.bjbas.2017.05.009]
[10]
Patel K, Gadewar M, Tahilyani V, Patel DK. A review on pharmacological and analytical aspects of diosmetin: A con-cise report. Chin J Integr Med 2013; 19(10): 792-800.
[http://dx.doi.org/10.1007/s11655-013-1595-3] [PMID: 24092244]
[11]
Imran M, Rauf A, Abu-Izneid T, et al. Luteolin, a flavonoid, as an anticancer agent: A review. Biomed Pharmacother 2019; 112: 108612.
[http://dx.doi.org/10.1016/j.biopha.2019.108612] [PMID: 30798142]
[12]
Patel K, Gadewar M, Tripathi R, Prasad SK, Patel DK. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”. Asian Pac J Trop Biomed 2012; 2(8): 660-4.
[http://dx.doi.org/10.1016/S2221-1691(12)60116-6] [PMID: 23569990]
[13]
Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J Tradit Complement Med 2016; 7(3): 360-6.
[http://dx.doi.org/10.1016/j.jtcme.2016.11.003] [PMID: 28725632]
[14]
Patel K, Singh GK, Patel DK. A review on pharmacological and analytical aspects of naringenin. Chin J Integr Med 2018; 24(7): 551-60.
[http://dx.doi.org/10.1007/s11655-014-1960-x] [PMID: 25501296]
[15]
Liao X-D, Wen Q, Zhang L-Y, Lu L, Zhang L-Y, Luo X-G. Effect of dietary supplementation with flavonoid from Scu-tellaria baicalensis Georgi on growth performance, meat quality and antioxidative ability of broilers. J Integr Agric 2018; 17: 1165-70.
[http://dx.doi.org/10.1016/S2095-3119(17)61803-3]
[16]
Papademetrio DL, Trabucchi A, Cavaliere V, Ricco R, Costantino S, Wagner ML. The catechin flavonoid reduces proli-feration and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins. Rev Bras Farmacogn 2013; 23: 455-63.
[http://dx.doi.org/10.1590/S0102-695X2013005000025]
[17]
Conforti F, Menichini F, Rigano D, Senatore F. Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Z Naturforsch C J Biosci 2009; 64(7-8): 490-4.
[http://dx.doi.org/10.1515/znc-2009-7-804] [PMID: 19791498]
[18]
Lee H-U, Bae E-A, Kim D-H. Hepatoprotective effects of irisolidone on tert-butyl hyperoxide-induced liver injury. Biol Pharm Bull 2005; 28(3): 531-3.
[http://dx.doi.org/10.1248/bpb.28.531] [PMID: 15744084]
[19]
Han Y-O, Han MJ, Park S-H, Kim D-H. Protective effects of kakkalide from Flos puerariae on ethanol-induced lethali-ty and hepatic injury are dependent on its biotransformation by human intestinal microflora. J Pharmacol Sci 2003; 93(3): 331-6.
[http://dx.doi.org/10.1254/jphs.93.331] [PMID: 14646251]
[20]
Xu Y, Ding L, Wang Z, Wang Y, Sun L. Virtual screening of cablin patchouli herb as a treatment for heat stress: A study based on network pharmacology, molecular docking, and experimental verification. Evid Based Complement Alternat Med 2021; 2021: 8057587.
[http://dx.doi.org/10.1155/2021/8057587] [PMID: 33777163]
[21]
Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A review on traditional uses, pharmacology, and phytoche-mistry. Front Pharmacol 2021; 11: 582506.
[http://dx.doi.org/10.3389/fphar.2020.582506] [PMID: 33708108]
[22]
Mykhailenko O, Korinek M, Ivanauskas L, et al. Qualitative and quantitative analysis of Ukrainian Iris species: A fresh look on their antioxidant content and biological activities. Molecules 2020; 25(19): 4588.
[http://dx.doi.org/10.3390/molecules25194588] [PMID: 33050063]
[23]
Xue Y, Li H, Zhang Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch 2018; 470(10): 1473-83.
[http://dx.doi.org/10.1007/s00424-018-2170-8] [PMID: 29961148]
[24]
Jang H-M, Park K-T, Noh H-D, Lee S-H, Kim D-H. Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria popula-tion. Int Immunopharmacol 2019; 73: 246-53.
[http://dx.doi.org/10.1016/j.intimp.2019.05.008] [PMID: 31112869]
[25]
Min S-W, Park Y-J, Kim D-H. Kakkalide and its metabolite irisolidone ameliorate carrageenan-induced inflammation in mice by inhibiting NF-κB pathway. Inflammation 2011; 34(5): 344-51.
[http://dx.doi.org/10.1007/s10753-010-9240-1] [PMID: 20686830]
[26]
Park J-S, Woo M-S, Kim D-H, et al. Anti-inflammatory mechanisms of isoflavone metabolites in lipopolysaccharide-stimulated microglial cells. J Pharmacol Exp Ther 2007; 320(3): 1237-45.
[http://dx.doi.org/10.1124/jpet.106.114322] [PMID: 17194798]
[27]
Conforti F, Rigano D, Menichini F, Loizzo MR, Senatore F. Protection against neurodegenerative diseases of Iris pseu-dopumila extracts and their constituents. Fitoterapia 2009; 80(1): 62-7.
[http://dx.doi.org/10.1016/j.fitote.2008.10.005] [PMID: 19000749]
[28]
Yuan D, Xie Y-Y, Bai X, Wu X, Yang J-Y, Wu C-F. Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. J Asian Nat Prod Res 2009; 11(6): 471-81.
[http://dx.doi.org/10.1080/10286020902819822] [PMID: 20183278]
[29]
Yamaki K, Kim D-H, Ryu N, Kim YP, Shin KH, Ohuchi K. Effects of naturally occurring isoflavones on prostaglandin E2 production. Planta Med 2002; 68(2): 97-100.
[http://dx.doi.org/10.1055/s-2002-20263] [PMID: 11859455]
[30]
Kang G-D, Lee S-Y, Jang S-E, Han MJ, Kim D-H. Irisolidone attenuates ethanol-induced gastric injury in mice by inhibi-ting the infiltration of neutrophils. Mol Nutr Food Res 2017; 61(2): 1600517.
[http://dx.doi.org/10.1002/mnfr.201600517] [PMID: 27546737]
[31]
Bae E-A, Han MJ, Kim D-H. In vitro anti-Helicobacter pylori activity of irisolidone isolated from the flowers and rhi-zomes of Pueraria thunbergiana. Planta Med 2001; 67(2): 161-3.
[http://dx.doi.org/10.1055/s-2001-11499] [PMID: 11301866]
[32]
Wollenweber E, Stevens JF, Klimo K, Knauft J, Frank N, Gerhäuser C. Cancer chemopreventive in vitro activities of isoflavones isolated from Iris germanica. Planta Med 2003; 69(1): 15-20.
[http://dx.doi.org/10.1055/s-2003-37030] [PMID: 12567273]
[33]
Nazir N, Koul S, Qurishi MA, et al. Immunomodulatory activity of isoflavones isolated from Iris germanica (Iridaceae) on T-lymphocytes and cytokines. Phytother Res 2009; 23(3): 428-33.
[http://dx.doi.org/10.1002/ptr.2683] [PMID: 19003948]
[34]
Kim JM, Yun-Choi HS. Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica. Arch Pharm Res 2008; 31(7): 886-90.
[http://dx.doi.org/10.1007/s12272-001-1242-1] [PMID: 18704331]
[35]
Kang KA, Zhang R, Piao MJ, et al. Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect. Bioorg Med Chem 2008; 16(3): 1133-41.
[http://dx.doi.org/10.1016/j.bmc.2007.10.085] [PMID: 17996449]
[36]
Ibrahim SRM, Mohamed GA, Zayed MF, Ross SA. 8-Hydroxyirilone 5-methyl ether and 8-hydroxyirilone, new an-tioxidant and α-amylase inhibitors isoflavonoids from Iris germanica rhizomes. Bioorg Chem 2017; 70: 192-8.
[http://dx.doi.org/10.1016/j.bioorg.2016.12.010] [PMID: 28069265]
[37]
Min S-W, Kim D-H. Kakkalide and irisolidone: HMG-CoA reductase inhibitors isolated from the flower of Pueraria thunbergiana. Biol Pharm Bull 2007; 30(10): 1965-8.
[http://dx.doi.org/10.1248/bpb.30.1965] [PMID: 17917273]
[38]
Shin JE, Bae E-A, Lee YC, Ma J-Y, Kim D-H. Estrogenic effect of main components kakkalide and tectoridin of Pue-rariae flos and their metabolites. Biol Pharm Bull 2006; 29(6): 1202-6.
[http://dx.doi.org/10.1248/bpb.29.1202] [PMID: 16755017]
[39]
Morito K, Aomori T, Hirose T, et al. Interaction of phytoestrogens with estrogen receptors alpha and beta (II). Biol Pharm Bull 2002; 25(1): 48-52.
[http://dx.doi.org/10.1248/bpb.25.48] [PMID: 11824555]
[40]
Qu J, Wu Z, Gao J, Wen H, Wang T, Yuan D. Excretion of tectoridin metabolites in rat urine and bile orally adminis-trated at different dosages and their inhibitory activity against aldose reductase. Fitoterapia 2014; 99: 99-108.
[http://dx.doi.org/10.1016/j.fitote.2014.09.009] [PMID: 25256063]
[41]
Kim S-Y, Lee E-J, Woo M-S, et al. Inhibition of matrix metalloproteinase-9 gene expression by an isoflavone metabo-lite, irisolidone in U87MG human astroglioma cells. Biochem Biophys Res Commun 2008; 366(2): 493-9.
[http://dx.doi.org/10.1016/j.bbrc.2007.11.178] [PMID: 18070596]
[42]
Kim S-Y, Kim D-H, Hyun J-W, Henson JW, Kim H-S. Irisolidone, an isoflavone metabolite, represses JC virus gene ex-pression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun 2006; 344(1): 3-8.
[http://dx.doi.org/10.1016/j.bbrc.2006.03.165] [PMID: 16630573]
[43]
Zhang G, Qi W, Xu L, Kano Y, Yuan D. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determi-ned by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2015; 1005: 23-9.
[http://dx.doi.org/10.1016/j.jchromb.2015.09.040] [PMID: 26465087]
[44]
Zhang G, Gong T, Kano Y, Yuan D. Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2014; 947-948: 117-24.
[http://dx.doi.org/10.1016/j.jchromb.2013.12.017] [PMID: 24412694]
[45]
Bai X, Qu J, Lu J, Kano Y, Yuan D. Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MSn. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879(5-6): 395-402.
[http://dx.doi.org/10.1016/j.jchromb.2010.12.025] [PMID: 21256817]
[46]
Wang H, Bai X, Sun J, Kano Y, Makino T, Yuan D. Metabolism and excretion of kakkalide and its metabolites in rat urine, bile, and feces as determined by HPLC/UV and LC/MS/MS. Planta Med 2013; 79(16): 1552-7.
[http://dx.doi.org/10.1055/s-0033-1350832] [PMID: 24108437]
[47]
Zhang G, Sun J, Kano Y, Yuan D. Metabolic profile of irisolidone in rats obtained by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 941: 1-9.
[http://dx.doi.org/10.1016/j.jchromb.2013.09.033] [PMID: 24184829]
[48]
Shi Z, Zhang G, Zhao L, Wang S, Kano Y, Yuan D. Excretion of tectorigenin in rat urine orally administrated at diffe-rent dosages by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Eur J Drug Metab Pharmacokinet 2015; 40(3): 255-66.
[http://dx.doi.org/10.1007/s13318-014-0202-0] [PMID: 24789580]
[49]
Bai X, Xie Y, Liu J, Qu J, Kano Y, Yuan D. Isolation and identification of urinary metabolites of kakkalide in rats. Drug Metab Dispos 2010; 38(2): 281-6.
[http://dx.doi.org/10.1124/dmd.109.028555] [PMID: 19910516]
[50]
Asghar SF. Habib-ur-Rehman, Atta-ur-Rahman, Choudhary M.I. Phytochemical investigations on Iris germanica. Nat Prod Res 2010; 24(2): 131-9.
[http://dx.doi.org/10.1080/14786410802435950] [PMID: 20077306]
[51]
Nazir N, Koul S, Qurishi MA, Taneja SC, Purnima B, Qazi GN. New isoflavones from Iris kashmiriana. J Asian Nat Prod Res 2008; 10(11-12): 1137-41.
[http://dx.doi.org/10.1080/10286020802413296] [PMID: 19031259]
[52]
Roger B, Jeannot V, Fernandez X, Cerantola S, Chahboun J. Characterisation and quantification of flavonoids in Iris germanica L. and Iris pallida Lam. resinoids from Morocco. Phytochem Anal 2012; 23(5): 450-5.
[http://dx.doi.org/10.1002/pca.1379] [PMID: 22213588]
[53]
Ibrahim SRM, Mohamed GA, Al-Musayeib NM. New constituents from the rhizomes of Egyptian Iris germanica L. Molecules 2012; 17(3): 2587-98.
[http://dx.doi.org/10.3390/molecules17032587] [PMID: 22388969]
[54]
Liu L, Ma Y, Chen X, Xiong X, Shi S. Screening and identification of BSA bound ligands from Puerariae lobata flower by BSA functionalized Fe3O4 magnetic nanoparticles coupled with HPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 887-888: 55-60.
[http://dx.doi.org/10.1016/j.jchromb.2012.01.008] [PMID: 22305973]
[55]
Farag MA, Huhman DV, Dixon RA, Sumner LW. Metabolomics reveals novel pathways and differential mechanistic and elicitor-specific responses in phenylpropanoid and isoflavonoid biosynthesis in Medicago truncatula cell cultures. Plant Physiol 2008; 146(2): 387-402.
[http://dx.doi.org/10.1104/pp.107.108431] [PMID: 18055588]
[56]
Fonseca FN, Ferreira AJS, Sartorelli P, et al. Phenylpropanoid derivatives and biflavones at different stages of differen-tiation and development of Araucaria angustifolia. Phytochemistry 2000; 55(6): 575-80.
[http://dx.doi.org/10.1016/S0031-9422(00)00239-9] [PMID: 11130667]
[57]
Hoensch HP, Oertel R. The value of flavonoids for the human nutrition: Short review and perspectives. Clin Nutr Exp 2015; 3: 8-14.
[http://dx.doi.org/10.1016/j.yclnex.2015.09.001]
[58]
Patel K, Patel DK. Therapeutic benefit and biological importance of ginkgetin in the medicine: Medicinal importance, pharmacological activities and analytical aspects. Curr Bioact Compd 2021; 17.
[http://dx.doi.org/10.2174/1573407217666210127091221]
[59]
Yadavalli R, Peasari JR, Mamindla P. Praveenkumar, Mounika S, Ganugapati J. Phytochemical screening and in silico studies of flavonoids from Chlorella pyrenoidosa. Informatics Med Unlocked 2018; 10: 89-99.
[http://dx.doi.org/10.1016/j.imu.2017.12.009]
[60]
Patel DK. Biological importance, therapeutic benefit and analytical aspects of bioactive flavonoid pectolinarin in the nature. Drug Metab Lett 2021; 14(2): 117-25.
[http://dx.doi.org/10.2174/1872312814666210726112910] [PMID: 34313205]

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