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Review Article

Overview on Thioredoxin-Interacting Protein (TXNIP): A Potential Target for Diabetes Intervention

Author(s): Rajesh Basnet*, Til Bahadur Basnet, Buddha Bahadur Basnet and Sandhya Khadka

Volume 23, Issue 7, 2022

Published on: 14 April, 2022

Page: [761 - 767] Pages: 7

DOI: 10.2174/1389450123666220303092324

Price: $65

Abstract

Background: Diabetes mellitus (DM) is a common metabolic disorder characterized by a persistent increment of blood glucose. Type 2 DM is characterized by insulin resistance and β-cell dysfunction. Thioredoxin-interacting protein (TXNIP) is among the factors that control the production and loss of pancreatic β-cells.

Objective: Recent studies have shown that high glucose can significantly up-regulate the expression of the TXNIP. Overexpression of TXNIP in β-cells not only induced apoptosis but also decreased the production of insulin. At the same time, TXNIP deficiency protected the apoptosis of β-cells, leading to increased insulin production. Therefore, finding small molecules that can modulate TXNIP expression and downstream signalling pathways is essential. Thus, the inhibition of TXNIP has beneficial effects on the cardiovascular system and other tissues such as the heart and the kidney in DM. Therefore, DM treatment must target small TXNIP activity, inhibit expression, and promote endogenous cell mass and insulin production.

Conclusion: This review briefly describes the effect mechanism, regulatory mechanism, and crystal structure of TXNIP. In addition, we highlight how TXNIP signalling networks contribute to diabetes and interact with drugs that inhibit the development often and its complexes. Finally, the current status and prospects of TXNIP targeted therapy are also discussed.

Keywords: TXNIP, β-cells, DM, FOXO1, ChREBP, insulin.

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