Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action

Title:Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action

Volume: 29 Issue: 2

Author(s): Yonghong Zhang, Changjie Bao, Lijun Shen, Chunjie Tian, Xueli Zang, Guang Chen*Sitong Zhang*

Affiliation:

• College of Life Sciences, Jilin Agricultural University, Changchun, China
• Key Laboratory of Straw Biology and Utilization, The Ministry of Education, Changchun, China

• College of Life Sciences, Jilin Agricultural University, Changchun, China
• Key Laboratory of Straw Biology and Utilization, The Ministry of Education, Changchun, China

Keywords: Cold shock protein, transcription, translation, csp mRNA, 5¢-UTR, RNA chaperone.

Abstract: The organism responds to a decrease in temperature by producing a series of cold shock proteins (CSPs). These proteins play a critical role in growing and functioning characteristics at low temperatures. CSPs have been discovered in a wide range of organisms and have shown enormous diversity; their mechanisms of action are also complicated. Transcription and translation in microorganisms typically occur via a single linear chain, but upon exposure to low temperatures, RNA forms a complex secondary structure that prevents ribosomes from binding to it, thus slowing down translation. CSPs bind to mRNA as RNA molecular chaperones to keep the mRNA secondary structure in a single-stranded linear conformation, allowing successful translation at low temperatures.

Cite this article as:

Zhang Yonghong , Bao Changjie, Shen Lijun , Tian Chunjie , Zang Xueli, Chen Guang*, Zhang Sitong*, Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action, Protein & Peptide Letters 2022; 29 (2) . https://dx.doi.org/10.2174/0929866528666211118084519