Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold

Title:Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold

Volume: 25 Issue: 23

Author(s): Ankita Chaudhary*

Affiliation:

• Department of Chemistry, Maitreyi College, University of Delhi, New Delhi,India

Keywords: Pyrido[2, 3-d]pyrimidine, multicomponent reactions, fused heterocycles, one-pot synthesis, sustainable chemistry, biological activities.

Abstract: Pyrido[2,3-d]pyrimidine is an N-fused heterocyclic compound formed by the ortho fusion of pyridine and pyrimidine ring. Pyrido[2,3-d]pyrimidines hold a prominent position in medicinal chemistry owing to their wide spectrum of biological activities like antiviral, antihistaminic, antibacterial, diuretic, anti-inflammatory, analgesic, anticonvulsive, antipyretic, etc. The extraordinary features of pyrido[2,3-d]pyrimidines make their synthesis a perpetual field of research. Moreover, the construction of elaborate biologically relevant moieties via a multicomponent approach has become a promising area of research, owing to the burgeoning ‘green chemistry drive’. Advances in the exploitation of proficient synthetic routes involving a multicomponent approach for the assembly of this scaffold are reported in this review.

Cite this article as:

Chaudhary Ankita*, Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold, Current Organic Chemistry 2021; 25 (23) . https://dx.doi.org/10.2174/1385272825666211117152900