Abstract
Pyrido[2,3-d]pyrimidine is an N-fused heterocyclic compound formed by the ortho fusion of pyridine and pyrimidine ring. Pyrido[2,3-d]pyrimidines hold a prominent position in medicinal chemistry owing to their wide spectrum of biological activities like antiviral, antihistaminic, antibacterial, diuretic, anti-inflammatory, analgesic, anticonvulsive, antipyretic, etc. The extraordinary features of pyrido[2,3-d]pyrimidines make their synthesis a perpetual field of research. Moreover, the construction of elaborate biologically relevant moieties via a multicomponent approach has become a promising area of research, owing to the burgeoning ‘green chemistry drive’. Advances in the exploitation of proficient synthetic routes involving a multicomponent approach for the assembly of this scaffold are reported in this review.
Keywords: Pyrido[2, 3-d]pyrimidine, multicomponent reactions, fused heterocycles, one-pot synthesis, sustainable chemistry, biological activities.
Current Organic Chemistry
Title:Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold
Volume: 25 Issue: 23
Author(s): Ankita Chaudhary*
Affiliation:
- Department of Chemistry, Maitreyi College, University of Delhi, New Delhi,India
Keywords: Pyrido[2, 3-d]pyrimidine, multicomponent reactions, fused heterocycles, one-pot synthesis, sustainable chemistry, biological activities.
Abstract: Pyrido[2,3-d]pyrimidine is an N-fused heterocyclic compound formed by the ortho fusion of pyridine and pyrimidine ring. Pyrido[2,3-d]pyrimidines hold a prominent position in medicinal chemistry owing to their wide spectrum of biological activities like antiviral, antihistaminic, antibacterial, diuretic, anti-inflammatory, analgesic, anticonvulsive, antipyretic, etc. The extraordinary features of pyrido[2,3-d]pyrimidines make their synthesis a perpetual field of research. Moreover, the construction of elaborate biologically relevant moieties via a multicomponent approach has become a promising area of research, owing to the burgeoning ‘green chemistry drive’. Advances in the exploitation of proficient synthetic routes involving a multicomponent approach for the assembly of this scaffold are reported in this review.
Export Options
About this article
Cite this article as:
Chaudhary Ankita*, Multicomponent Approach for the Sustainable Syntheses of Pyrido[2,3-d]pyrimidine Scaffold, Current Organic Chemistry 2021; 25 (23) . https://dx.doi.org/10.2174/1385272825666211117152900
DOI https://dx.doi.org/10.2174/1385272825666211117152900 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements