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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Mini-Review Article

DNA Nanodevices: From Mechanical Motions to Biomedical Applications

Author(s): Yiming Wang, Zhaoran Wang, Xiaohui Wu, Shaoli Liu, Fengsong Liu, Qiao Jiang* and Baoquan Ding*

Volume 22, Issue 8, 2022

Published on: 19 January, 2022

Page: [640 - 651] Pages: 12

DOI: 10.2174/1568026621666211105100240

Price: $65

Abstract

Inspired by molecular machines in nature, artificial nanodevices have been designed to realize various biomedical functions. Self-assembled deoxyribonucleic acid (DNA) nanostructures that feature designed geometries, excellent spatial accuracy, nanoscale addressability, and marked biocompatibility provide an attractive candidate for constructing dynamic nanodevices with biomarker- targeting and stimuli-responsiveness for biomedical applications. Here, a summary of typical construction strategies of DNA nanodevices and their operating mechanisms are presented. We also introduced recent advances in employing DNA nanodevices as platforms for biosensing and intelligent drug delivery. Finally, the broad prospects and main challenges of the DNA nanodevices in biomedical applications are also discussed.

Keywords: Artificial nanodevices, Biomedical applications, DNA nanotechnology, Biosensing, Drug delivery, Mechanical motions.

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