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Mini-Review Article

血小板在严重和致命形式的 COVID-19 中的作用

卷 22, 期 7, 2022

发表于: 24 February, 2022

页: [572 - 583] 页: 12

弟呕挨: 10.2174/1566524021666210910112404

价格: $65

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摘要

2019年12月31日，世界卫生组织收到中国武汉多起肺炎病例报告。病原体后来被确认为严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2)。从那时起，SARS-CoV-2 病毒在世界范围内传播，并在 2020 年引发了 2019 年冠状病毒 (COVID-19) 大流行，根据世界卫生组织的世界地图，该流行病一直持续到 5 月 18 日， 2021年，全球感染163,312,429人，造成3,386,825人死亡。大多数危重患者迅速发展为急性呼吸窘迫综合征（ARDS），并且据报道，感染性休克、不可逆代谢性酸中毒、凝血功能障碍或止血和血栓形成异常是导致 COVID-19 死亡的主要原因。在严重和致命的 COVID-19 患者中的主要发现清楚地表明，血小板在严重疾病病例的发展中起着至关重要的作用。血小板是负责止血和血栓形成的去核细胞；因此，促炎微环境诱导的血小板高反应性有助于“细胞因子风暴”，这是 COVID-19 更具侵袭性过程的特征。

关键词: COVID-19、SARS-COV-2、血小板、细胞因子风暴、几种 COVID 形式、致命的 COVID 形式。

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