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Review Article

以甘油三酯代谢为靶点防治大肠癌

卷 23, 期 6, 2022

发表于: 24 August, 2021

页: [628 - 635] 页: 8

弟呕挨: 10.2174/1389450122666210824150012

价格: $65

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摘要

背景:甘油三酯（TG）是人体脂肪和能量库的主要成分之一，由甘油衍生的酯和三种游离脂肪酸组成。TG脂肪酶、单酰甘油脂肪酶、脂肪酸合成酶和HMG-CoA还原酶是TG代谢相关的关键酶，它们在结直肠癌（CRC）发生和发展中的作用正在研究中。 方法:基于已发表的各种文献进行文献检索，主要是PubMed、谷歌Scholar等搜索引擎中与CRC相关的甘油三酯代谢。利用R程序和cBioportal软件从The Cancer Genome Atlas（TCGA）数据库获取转录组和/或蛋白质组数据，对TG代谢途径的部分介质进行基因表达谱分析。 结果和讨论:越来越多的证据表明TG谱可作为CRC诊断和/或预后的生物标志物。TG代谢异常与结直肠癌的发生和发展有关。根据文献检索，并结合TCGA数据，在CRC发生过程中，TG合成代谢途径的大部分介质均过表达和/或过活化，而TG分解代谢途径的大部分介质均下调和/或失活。TG和FAs代谢通路的代谢酶参与了CRC肿瘤的生长、生存和转移。 结论:从以往文献的整体研究和我们的TCGA数据分析表明，TG相关脂质代谢途径的研究领域具有很大的前景，并有必要在该领域开展详细的研究，以实施新的CRC预防和治疗策略。

关键词: 甘油三酯代谢，大肠癌，代谢酶，化学预防，药物靶标，甘油三酯。

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