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Review Article

脂肪细胞脂肪酸结合蛋白（A-FABP）是治疗肥胖相关癌症的潜在新靶点

卷 23, 期 6, 2022

发表于: 12 July, 2021

页: [597 - 605] 页: 9

弟呕挨: 10.2174/1389450122666210712193654

价格: $65

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摘要

脂肪酸结合蛋白A（A-FABP）是主要存在于脂肪组织和巨噬细胞中的FABPs亚型之一。它通过多种综合途径发挥作用，调节炎症和脂质代谢，促进葡萄糖生成，损害胰岛素功能，并促进动脉粥样硬化和糖尿病等疾病。A-FABP在肥胖患者的脂肪组织中上调，其释放到血液中的增加与体重指数呈正相关。因此，A-FABP在肥胖人群的代谢调节中起着关键作用。最近对小鼠模型和人类的研究表明，A-FABP在增加肥胖相关癌症风险方面的作用。本文就肥胖、癌症与A-FABP作为肥胖相关癌症新的潜在治疗靶点的关系的研究现状进行综述。

关键词: 脂肪酸结合蛋白，脂肪细胞，癌症，肥胖，代谢综合征，代谢。

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图形摘要

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