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摘要
脂肪酸结合蛋白A(A-FABP)是主要存在于脂肪组织和巨噬细胞中的FABPs亚型之一。它通过多种综合途径发挥作用,调节炎症和脂质代谢,促进葡萄糖生成,损害胰岛素功能,并促进动脉粥样硬化和糖尿病等疾病。A-FABP在肥胖患者的脂肪组织中上调,其释放到血液中的增加与体重指数呈正相关。因此,A-FABP在肥胖人群的代谢调节中起着关键作用。最近对小鼠模型和人类的研究表明,A-FABP在增加肥胖相关癌症风险方面的作用。本文就肥胖、癌症与A-FABP作为肥胖相关癌症新的潜在治疗靶点的关系的研究现状进行综述。
关键词: 脂肪酸结合蛋白,脂肪细胞,癌症,肥胖,代谢综合征,代谢。
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