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摘要
脂质组学是一种新兴和有前途的组学,用于分析生物样本中的不同脂质分子。它被认为是代谢组学的一个分支,代谢组学的定义是对生物标本中的代谢物进行综合分析。尽管如此,近年来脂质组学在生物医学领域被认为是一门独特的学科。脂质在许多生物学途径中发挥着重要作用,可以作为疾病的生物标志物或治疗疾病的治疗靶点。主要的脂质组学策略是鸟枪法脂质组学和液相色谱-质谱联用。胃肠疾病如肠易激综合征或炎症性肠病是慢性疾病,需要非侵入性生物标志物进行预后和诊断。此外,炎症性肠病患者发生结直肠癌的风险显著增加,主要是由于慢性肠道炎症的促肿瘤作用。目前全球使用的筛查方法包括乙状结肠镜或标准结肠镜,但开发无创、准确的筛查工具以促进结肠直肠癌的早期发现和精确分期是很重要的。疾病进展和对治疗的反应也可能受益于这些潜在的新工具的应用。这篇综述集中在使用脂质组学方法来发现监测上述肠道疾病,特别是肿瘤进展的潜在生物标志物的研究。
关键词: 脂质组学,肠易激综合征,炎症性肠病,结直肠癌,生物标志物,组学。
Current Drug Targets
Title:Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irritable Bowel Syndrome to Colorectal Cancer
Volume: 23 Issue: 6
关键词: 脂质组学,肠易激综合征,炎症性肠病,结直肠癌,生物标志物,组学。
摘要: Lipidomics is an emerging and promising omic that analyzes different lipid molecules in a biological sample. It is considered as a branch of metabolomics, which is defined as the comprehensive analysis of metabolites in a biological specimen. Nonetheless, in recent years lipidomics is being considered a distinct discipline in the biomedicine field. Lipids play important roles in many biological pathways and could work as biomarkers of disease or as therapeutic targets for treatment diseases. The major lipidomics strategies are shotgun lipidomics and liquid chromatography coupled with mass spectrometry. Gastrointestinal diseases such as irritable bowel syndrome or inflammatory bowel disease are chronic diseases that need non-invasive biomarkers for prognosis and diagnosis. Even more, patients with inflammatory bowel disease are at a significantly increased risk of colorectal cancer, principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Current screening methods utilized globally include sigmoidoscopy, or standard colonoscopy but it is important to develop non-invasive and accurate screening tools to facilitate early detection and precise staging of colorectal cancer. Disease progression and response to treatment may benefit also from the application of these potential new tools. This review is focused on studies that use lipidomics approaches to discover potential biomarkers for monitoring the mentioned intestinal diseases and, particularly, tumour progression.
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Cite this article as:
Lipidomics as Tools for Finding Biomarkers of Intestinal Pathology: From Irritable Bowel Syndrome to Colorectal Cancer, Current Drug Targets 2022; 23 (6) . https://dx.doi.org/10.2174/1389450122666210707122151
DOI https://dx.doi.org/10.2174/1389450122666210707122151 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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