Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy

Title:Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy

Volume: 23 Issue: 4

Author(s): Shahin Aghamiri*, Pourya Raee, Shiva Shahmohamadnejad, Sasan Shabani, Jaber Ghorbani, Marzieh Sameni and Mohammad Taha Ebrahimi

Affiliation:

• Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
• Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Keywords: Prostate cancer, nanoparticles, siRNA, drug delivery systems, multidrug resistance, combination therapy.

Abstract: Abstract: The critical problems of conventional prostate cancer therapeutic strategies like nonspecific toxicity and multi-drug resistance prompted the development and application of countless nanoparticle- based siRNA therapeutics. Unfortunately, siRNA-based therapeutics suffer from the lack of safe and effective delivery systems, immune system stimulation, poor knowledge of nano-bio interactions, and limitations concerning designing, manufacturing, clinical translation, and commercialization. In this review, we provide cutting-edge advances in nanoparticle-mediated siRNA delivery carriers like polymeric systems, lipid systems, specific systems, and rigid nanoparticles for the treatment of prostate cancer. Moreover, co-delivery of conventional chemotherapy drugs with siRNA as a revolutionary robust strategy for prostate cancer combinational therapy is completely covered.

Cite this article as:

Aghamiri Shahin*, Raee Pourya, Shahmohamadnejad Shiva, Shabani Sasan, Ghorbani Jaber, Sameni Marzieh and Ebrahimi Taha Mohammad, Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy, Current Pharmaceutical Biotechnology 2022; 23 (4) . https://dx.doi.org/10.2174/1389201022666210615123211