Abstract
Psoriasis is an immune-mediated chronic skin inflammation. This disease can be associated with several manifestations like red flakes, silver scales, patches, plaques, and silvery-white squams. Approximately 70% of the patients treated with topical dosage forms have a mild-to-moderate form of psoriasis, whereas a moderate-to-severe form of psoriasis is treated with systemic, photo, and biological therapies. Considering the big fraction that topicals cover, we present the current market potential, clinical relevance, and recent advances in the topical delivery of the drug for psoriasis. Though we witnessed several advancements in the recent few decades, delivering new immunomodulatory and biological molecules for topical psoriatic treatment have been proven to be efficient and safe options for the large percentage of patients for whom systemic therapy is not indicated. This article enumerates the promising topical dosage forms at present under assessment for their clinical pertinence. The competency of conventional topicals to reach and transform the world market is enumerated in terms of their success rate after proving the clinical pertinence against psoriasis. However, the entrance of novel drug delivery systems based on advanced topical products in the global market is highly anticipated as they have immense potential to impact the psoriasis treatment in the near future.
Keywords: Psoriasis, topicals, drug delivery, market potential, clinical relevance, biologicals.
Current Drug Targets
Title:Recent Advancement in Topical Drug Delivery for Psoriasis: Clinical Pertinence and Potential Market
Volume: 22 Issue: 13
Author(s): Rakhi Kumari, Jitu Halder, Amit Sharma and Vineet Kumar Rai*
Affiliation:
- Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, 142001,India
Keywords: Psoriasis, topicals, drug delivery, market potential, clinical relevance, biologicals.
Abstract: Psoriasis is an immune-mediated chronic skin inflammation. This disease can be associated with several manifestations like red flakes, silver scales, patches, plaques, and silvery-white squams. Approximately 70% of the patients treated with topical dosage forms have a mild-to-moderate form of psoriasis, whereas a moderate-to-severe form of psoriasis is treated with systemic, photo, and biological therapies. Considering the big fraction that topicals cover, we present the current market potential, clinical relevance, and recent advances in the topical delivery of the drug for psoriasis. Though we witnessed several advancements in the recent few decades, delivering new immunomodulatory and biological molecules for topical psoriatic treatment have been proven to be efficient and safe options for the large percentage of patients for whom systemic therapy is not indicated. This article enumerates the promising topical dosage forms at present under assessment for their clinical pertinence. The competency of conventional topicals to reach and transform the world market is enumerated in terms of their success rate after proving the clinical pertinence against psoriasis. However, the entrance of novel drug delivery systems based on advanced topical products in the global market is highly anticipated as they have immense potential to impact the psoriasis treatment in the near future.
Export Options
About this article
Cite this article as:
Kumari Rakhi , Halder Jitu , Sharma Amit and Rai Kumar Vineet *, Recent Advancement in Topical Drug Delivery for Psoriasis: Clinical Pertinence and Potential Market, Current Drug Targets 2021; 22 (13) . https://dx.doi.org/10.2174/1389450122666210412124256
DOI https://dx.doi.org/10.2174/1389450122666210412124256 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
RNA Molecules in the Treatment of Human Diseases
Messenger and non-coding RNAs, including long and small transcripts, are mediators of gene expression. Gene expression at the RNA level shows significant aberrations in human diseases, including cancer, leukemia, lymphoma, cardiovascular diseases, and neurological disorders. Human transcripts serve either as biomarkers of diagnosis, prognosis, prediction of treatment response and/or therapy ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Permeation of Hydroxypropyl-Beta-Cyclodextrin and Its Inclusion Complex Through Mouse Small Intestine Determined by Spectrophotometry
Current Pharmaceutical Analysis Synthetic Aziridines in Medicinal Chemistry: A Mini-Review
Mini-Reviews in Medicinal Chemistry Biosensors for Antioxidant Evaluation in Biological Systems
Combinatorial Chemistry & High Throughput Screening Erythropoietin and mTOR: A “One-Two Punch” for Aging-Related Disorders Accompanied by Enhanced Life Expectancy
Current Neurovascular Research Novel Dual Inhibitors of Nuclear Factor-Kappa B (NF-κ B) and Cyclooxygenase- 2 (COX-2): Synthesis, In Vitro Anticancer Activity and Stability Studies of Lantadene–Non Steroidal Anti-inflammatory Drug (NSAID) Conjugates
Current Topics in Medicinal Chemistry The Implications of Urine Drug Testing in Pain Management
Current Drug Safety Intelligent Hydrogels for Drug Delivery System
Recent Patents on Drug Delivery & Formulation Synthesis, Cytotoxicity and Docking Simulation of Novel Annulated Dihydroisoquinoline Heterocycles
Mini-Reviews in Medicinal Chemistry Pavlovian Sign-Tracking Model of Alcohol Abuse
Current Drug Abuse Reviews Chemoprevention of Skin Cancer: Effect of Lawsonia inermis L. (Henna) Leaf Powder and its Pigment Artifact, Lawsone in the Epstein- Barr Virus Early Antigen Activation Assay and in Two-Stage Mouse Skin Carcinogenesis Models
Anti-Cancer Agents in Medicinal Chemistry The Importance of Epitope Binning for Biological Drug Discovery
Current Drug Discovery Technologies Optimization of CDTE Quantum Dots Synthesis Using Capillary Zone Electrophoresis
Current Nanoscience 2D QSAR Studies on a Series of Quinazoline Derivatives as Tyrosine Kinase (EGFR) Inhibitor: An Approach to Design Anticancer Agents
Letters in Drug Design & Discovery Ligands and Therapeutic Perspectives of Adenosine A2A Receptors
Current Pharmaceutical Design The Dark Side of Stem Cells: Triggering Cancer Progression by Cell Fusion
Current Molecular Medicine An Insight into Pandemic COVID-19: Structure, Epidemiology and Therapeutics
Current Biotechnology Chemoradiotherapy in Rectal Cancer
Current Drug Therapy Bioactive Chromone Derivatives – Structural Diversity
Current Bioactive Compounds Asymmetric Dimethylarginine: A Possible Link between Vascular Disease and Dementia
Current Alzheimer Research Structure-Activity Relationships of Glutamate Carboxypeptidase II (GCPII) Inhibitors
Current Medicinal Chemistry