摘要
神经元是高能量利用组织。神经元细胞的呼吸速率高于其他细胞。细胞呼吸与线粒体一起发生。线粒体的健康生产和功能在维持健康的神经元中起着关键作用。在神经退行性疾病等病理状况下,健康的线粒体有助于缓解神经元细胞中的病理事件。相反,线粒体功能障碍会促进神经退行性过程的加速。此外,神经胶质来源的线粒体在调节健康神经元功能方面发挥多种作用。它还支持神经递质的释放;产生脉冲,调节膜电位和分子动力学;控制轴突运输;控制外周和中枢神经系统的线粒体裂变和融合功能。此外,它在神经元细胞的再生过程中起着关键作用。因此,健康的线粒体可以为神经元细胞功能提供健康的环境,并可以治疗神经退行性疾病。在这篇综述中,我们探讨了健康线粒体的当前观点及其在健康神经元功能中的作用。
关键词: Glial cell
Current Drug Targets
Title:Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons
Volume: 22 Issue: 14
关键词: Glial cell
摘要: The neuron is high-energy utilizing tissue. The rate of neuronal cell respiration is higher than in other cells. Cellular respiration occurs with mitochondria. The healthy production and functions of mitochondria play a key role in the maintenance of healthy neurons. In pathological conditions such as neurodegenerative diseases, healthy mitochondria help to alleviate pathological events in neuronal cells. Conversely, mitochondrial dysfunction promotes the acceleration of the neurodegenerative process. Furthermore, glial-derived mitochondria contribute to multiple roles in the regulation of healthy neuron functions. It also supports releasing of the neurotransmitters; generation of the impulses, regulation of the membrane potential and molecular dynamics; controlling of the axonal transport; controlling of the mitochondrial fission and fusion functions in the peripheral as well as the central nervous system. Moreover, it plays a key role in the regeneration process of neuronal cells. Therefore, healthy mitochondria can provide a healthy environment for neuronal cell function and can treat neurodegenerative disorders. In this review, we explore the current view of healthy mitochondria and their role in healthy neuronal functions.
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Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons, Current Drug Targets 2021; 22 (14) . https://dx.doi.org/10.2174/1389450122666210222163528
DOI https://dx.doi.org/10.2174/1389450122666210222163528 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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