摘要
细胞凋亡通常称为程序性细胞死亡,被定义为自我导向的细胞破坏过程。 由于在此过程中激活了半胱天冬酶,因此它与坏死不同。 细胞凋亡与癌症进展直接相关,在致癌过程中起着至关重要的作用; 所有细胞毒性药物和放射治疗程序都会启动肿瘤细胞的凋亡。 今天,研究表明含有三唑官能团的杂环化合物具有抗癌活性; 三唑是五元环,含有两个碳和三个氮原子。 因此,许多研究人员合成了这些小的活性化合物作为目标结构并评估了它们的凋亡活性。 本综述描述了过去几年中报道的三唑类作为抗癌剂的近期药用方面。 我们希望三唑衍生物的生物活性有利于新一代小分子药物的合理设计。
关键词: 细胞凋亡、三唑、癌症、caspase-8、caspase-3、Bcl-2、细胞色素 C。
Current Drug Targets
Title:Recent Progress on Apoptotic Activity of Triazoles
Volume: 22 Issue: 16
关键词: 细胞凋亡、三唑、癌症、caspase-8、caspase-3、Bcl-2、细胞色素 C。
摘要: Apoptosis is often called programmed cell death and is defined as a self-directed cell destruction process. It is different from necrosis due to the activation of caspases during this process. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotoxic drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5- membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic activities. The present review describes recent medicinal aspects of triazoles as anticancer agents that have been reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of a new generation of small molecule drugs.
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Recent Progress on Apoptotic Activity of Triazoles, Current Drug Targets 2021; 22 (16) . https://dx.doi.org/10.2174/1389450122666210208181128
DOI https://dx.doi.org/10.2174/1389450122666210208181128 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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