摘要
背景:炎症性肠病 (IBD) 的发病率在全球范围内持续上升。尽管药物治疗取得了进展,但克罗恩病 (CD) 和溃疡性结肠炎 (UC) 的发病机制仍未得到充分解释。迁移波是分析 IBD 流行的演变并推断其触发因素的具有挑战性的环境。 目的:我们的研究旨在概述有关第一代和第二代移民中 IBD 患病率和表型的文献。此外,我们旨在总结迁移历史并绘制与 IBD 分布的可能相关性。 方法:在对相关主题进行电子(PubMed 和 Web of Science)和手动搜索之后进行非系统性审查。 结果:总体而言,第一代移民倾向于保持本国的 IBD 风险。在下一代,风险往往会趋向于目的地国家的风险。较早的迁移年龄会调节 IBD 风险,这表明暴露于环境和社会经济因素的程度可能对疾病进展起决定性作用。一般来说,CD 需要更多时间才能达到与东道国相似的疾病负担,表明 UC 可能更多地受非遗传因素和遗传-非遗传相互作用的影响。 结论:IBD 表型和自然病程因移民和种族而异;然而,这些趋势在队列中并非一致。需要进一步研究分析遗传背景和环境风险因素对不同种族的影响,为识别高危个体、预防和早期诊断 IBD 提供证据。
关键词: 流行病学、克罗恩病、炎症性肠病、迁移、溃疡性结肠炎、危险因素。
Current Drug Targets
Title:Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?
Volume: 22 Issue: 15
关键词: 流行病学、克罗恩病、炎症性肠病、迁移、溃疡性结肠炎、危险因素。
摘要:
Background: The incidence of inflammatory bowel disease (IBD) continues to rise worldwide. Despite the advances in pharmacotherapy, the etiopathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) remains underexplained. The migratory waves are a challenging setting to analyze the evolution of IBD prevalence and to infer its triggering factors.
Objective: Our study aimed to overview the literature regarding IBD prevalence and phenotype in first- and second-generation migrants Also, we aimed to summarize the migration history and to draw a possible correlation with IBD distribution.
Methods: A non-systematic review was performed following electronic (PubMed and Web of Science) and manual searches on relevant topics.
Results: Overall, first-generation migrants tend to maintain the IBD risk of the native country. On the following generation, the risk tends to converge to that of the destination country. Earlier age at migration modulates IBD risk, suggesting that the degree of exposure to environmental and socio-economic factors can be decisive for disease progression. In general, CD needs more time to reach a disease burden similar to that of the host country, indicating that UC may be more affected by nongenetic factors and genetic-nongenetic interactions.
Conclusion: IBD phenotypes and natural history vary in migrants and according to ethnicity; however, the trends are not consensual among cohorts. Further studies are warranted to analyze the effect of genetic background and environmental risk factors in different ethnic groups, providing evidence to move towards the identification of at-risk individuals, prevention, and earlier diagnosis of IBD.
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Cite this article as:
Inflammatory Bowel Disease in Migrant Populations: Should we Look Even Further Back?, Current Drug Targets 2021; 22 (15) . https://dx.doi.org/10.2174/1389450122666210203193817
DOI https://dx.doi.org/10.2174/1389450122666210203193817 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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