Abstract
A classic reductive amidation/amination (C-N bond formation) approach for DNJ synthesis has been widely practiced due to the availability of low-cost reagents. The key steps for this synthetic route are Swern oxidation, reductive amidation/amination, and debenzylation. A lot of attention has been given to the optimization of these key intermediates apart from debenzylation. This review aims to describe the deprotection advances employing efficient, systematic, and practical protocols for sample preparation and separation by using Pd(OH)2/C, Li, BCl3 and Pd/C as catalysts. The impact of varying reaction parameters such as solvents, acids and temperature for deprotection was emphasized for optimal DNJ synthesis.
Keywords: 1-Deoxynojirimycin (DNJ), sugar source, chemical synthesis, reductive amidation/amination, deprotection, azasugars.
Graphical Abstract
Call for Papers in Thematic Issues
Active Alkaloids: Structure, Mechanism of Action, Chemical Synthesis, and Biosynthesis
The scope of this topic encompasses the structure, mechanism of action, chemical synthesis, and biosynthesis of active alkaloids. Alkaloids, a class of nitrogen-containing organic compounds with alkaline properties, originate from a diverse array of sources. Many alkaloids exhibit significant biological activities and serve as key constituents in numerous medicinal plants. ...read more
Advancements in Synthesis of Bioactive Compounds
This thematic issue focuses on elucidating advanced synthetic strategies for bioactive compounds, with the primary objective of deepening understanding of the rational design and construction of target molecules. The exploration encompasses a diverse range of techniques, established name reactions, and cutting-edge synthetic methodologies. Specifically, the issue delves into the synthesis ...read more
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Catalytic removal of toxic and harmful gases in complex environments
During a fire accident, carbon monoxide, carbon dioxide, sulfur dioxide, and other toxic and harmful gases are the main components of fire smoke but are also important factors causing fire casualties and damage to electronic equipment. Effective removal of carbon monoxide, carbon dioxide, sulfur dioxide, and other toxic and hazardous ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
34