MDAPlatform: A Component-based Platform for Constructing and Assessing miRNA-disease Association Prediction Methods

Title:MDAPlatform: A Component-based Platform for Constructing and Assessing miRNA-disease Association Prediction Methods

Volume: 16 Issue: 5

Author(s): Yayan Zhang, Guihua Duan, Cheng Yan*, Haolun Yi, Fang-Xiang Wu and Jianxin Wang

Affiliation:

• Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, 932 South Lushan Rd, 410083, Changsha,China
• School of Computer and Information, Qiannan Normal University for Nationalities, Longshan Road, 558000, Duyun, China

Keywords: MiRNA, disease, MicroRNA-disease association, constructing prediction methods, cross-language, componentbased platform.

Abstract:

Background: Increasing evidence has indicated that miRNA-disease association prediction plays a critical role in the study of clinical drugs. Researchers have proposed many computational models for miRNA-disease prediction. However, there is no unified platform to compare and analyze the pros and cons or share the code and data of these models.

Objective: In this study, we developed an easy-to-use platform (MDAPlatform) to construct and assess miRNA-disease association prediction method.

Methods: MDAPlatform integrates the relevant data of miRNA, disease and miRNA-disease associations that are used in previous miRNA-disease association prediction studies. Based on the componentized model, it develops different components of previous computational methods.

Results: Users can conduct cross validation experiments and compare their methods with other methods, and the visualized comparison results are also provided.

Conclusion: Based on the componentized model, MDAPlatform provides easy-to-operate interfaces to construct the miRNA-disease association method, which is beneficial to develop new miRNA-disease association prediction methods in the future.

Cite this article as:

Zhang Yayan , Duan Guihua , Yan Cheng *, Yi Haolun , Wu Fang-Xiang and Wang Jianxin , MDAPlatform: A Component-based Platform for Constructing and Assessing miRNA-disease Association Prediction Methods, Current Bioinformatics 2021; 16 (5) . https://dx.doi.org/10.2174/1574893616999210120181506