Abstract
The regulatory mechanisms lying over the genome that determines the differential expression of genes are termed epigenetic mechanisms. DNA methylation, acetylation, and phosphorylation of histone proteins and RNAi are typical examples. These epigenetic modifications are important determinants of normal growth and metabolism; at the same time, aberrant histone modifications play a major role in pathological conditions and are emerging as a new area of research for the last decades. Histone onco-modification is a term introduced by the scientific world to denote histone post-translational modifications that are associated with cancer development and progression. These modifications are likely to act in certain conditions as adaptive mechanisms to environmental and social factors. The enzymes that regulate DNA methylation as well as histone modifications are thus become a target for cancer therapy and chemoprevention. Since oxidative stress has been shown to modulate epigenetic changes, and phytocompounds with powerful antioxidant properties have a significant role in disease prevention. Nowadays, “nutri- epigenetics” is becoming an emerging area of research that deals with the influence of dietary compounds in epigenetics. This review aims to discuss the biological efficacy of promising phytocompounds that are able to counteract deleterious epigenetic modifications, especially histone onco- modifications.
Keywords: Phytocompounds, epigenetics, histone modification, DNA methylation, acetylation, phosphorylation.
Current Drug Targets
Title:Targeting Histone Onco- Modifications Using Plant-Derived Products
Volume: 22 Issue: 11
Author(s): Soorya P. Illam, Sruthi P. Kandiyil and Achuthan C. Raghavamenon*
Affiliation:
- Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala-680 555,India
Keywords: Phytocompounds, epigenetics, histone modification, DNA methylation, acetylation, phosphorylation.
Abstract: The regulatory mechanisms lying over the genome that determines the differential expression of genes are termed epigenetic mechanisms. DNA methylation, acetylation, and phosphorylation of histone proteins and RNAi are typical examples. These epigenetic modifications are important determinants of normal growth and metabolism; at the same time, aberrant histone modifications play a major role in pathological conditions and are emerging as a new area of research for the last decades. Histone onco-modification is a term introduced by the scientific world to denote histone post-translational modifications that are associated with cancer development and progression. These modifications are likely to act in certain conditions as adaptive mechanisms to environmental and social factors. The enzymes that regulate DNA methylation as well as histone modifications are thus become a target for cancer therapy and chemoprevention. Since oxidative stress has been shown to modulate epigenetic changes, and phytocompounds with powerful antioxidant properties have a significant role in disease prevention. Nowadays, “nutri- epigenetics” is becoming an emerging area of research that deals with the influence of dietary compounds in epigenetics. This review aims to discuss the biological efficacy of promising phytocompounds that are able to counteract deleterious epigenetic modifications, especially histone onco- modifications.
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Cite this article as:
Illam P. Soorya , Kandiyil P. Sruthi and Raghavamenon C. Achuthan *, Targeting Histone Onco- Modifications Using Plant-Derived Products, Current Drug Targets 2021; 22 (11) . https://dx.doi.org/10.2174/1389450122666210118150716
DOI https://dx.doi.org/10.2174/1389450122666210118150716 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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