Abstract
Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.
Keywords: Targeted radionuclide therapy (TRT), auger electrons, mercury-197 (197Hg), antimony-119 (119Sb), production, radiochemicalseparation, coordination, imaging, dosimetry.
Current Radiopharmaceuticals
Title:Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119
Volume: 14 Issue: 4
Author(s): Parmissa Randhawa, Aeli P. Olson, Shaohuang Chen, Kaley Lexi Gower-Fry, Cornelia Hoehr*, Jonathan W. Engle*, Caterina F. Ramogida*Valery Radchenko*
Affiliation:
- Department of Life Sciences Division, TRIUMF, Vancouver, BC,Canada
- Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI,United States
- Department of Chemistry, Simon Fraser University, Burnaby, BC,Canada
- Department of Life Sciences Division, TRIUMF, Vancouver, BC,Canada
Keywords: Targeted radionuclide therapy (TRT), auger electrons, mercury-197 (197Hg), antimony-119 (119Sb), production, radiochemicalseparation, coordination, imaging, dosimetry.
Abstract: Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.
Export Options
About this article
Cite this article as:
Randhawa Parmissa , Olson P. Aeli , Chen Shaohuang , Gower-Fry Lexi Kaley , Hoehr Cornelia *, Engle W. Jonathan *, Ramogida F. Caterina *, Radchenko Valery *, Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119, Current Radiopharmaceuticals 2021; 14 (4) . https://dx.doi.org/10.2174/1874471014999210111201630
DOI https://dx.doi.org/10.2174/1874471014999210111201630 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity
Mini-Reviews in Medicinal Chemistry Aminolevulinic Acid Derivatives and Liposome Delivery as Strategies for Improving 5-Aminolevulinic Acid- Mediated Photodynamic Therapy
Current Medicinal Chemistry Circumventing Immune Tolerance Through Epigenetic Modification
Current Pharmaceutical Design A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Zuogui Yin in the Treatment of Male Infertility
Combinatorial Chemistry & High Throughput Screening Crotamine, a Small Basic Polypeptide Myotoxin from Rattlesnake Venom with Cell-Penetrating Properties
Current Pharmaceutical Design Metal–Organic Framework (MOF)-based Nanomaterials for Biomedical Applications
Current Medicinal Chemistry Cranberry for Urinary Tract Infection: From Bench to Bedside
Current Topics in Medicinal Chemistry Potential Role of <i>In Vitro-In Vivo</i> Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs
Current Drug Targets Understanding the Role and Mechanism of Carbonic Anhydrase V in Obesity and its Therapeutic Implications
Current Protein & Peptide Science CD40L - A Multipotent Molecule for Tumor Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery
Current Medicinal Chemistry Emerging Role of Wnt/Beta-Catenin Signalling Pathways in Cancer Progression and Role of Small Molecule Tankyrase Inhibitors in Combating Multistage Cancers
Current Cancer Therapy Reviews Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy
Current Medicinal Chemistry Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System
Current Drug Targets Anti-Tumor Efficacy of Pyrvinium Pamoate Nanoliposomes in an Experimental Model of Melanoma
Anti-Cancer Agents in Medicinal Chemistry Curcumin: A Natural Product for Diabetes and its Complications
Current Topics in Medicinal Chemistry Exploring Cantharidin and its Analogues as Anticancer Agents: A Review
Current Medicinal Chemistry Applications of the Rare Earth Elements in Cancer Imaging and Therapy
Current Nanoscience Malignant and Benign Head and Neck Tumors of the Pediatric Age: A Narrative Review
Current Pediatric Reviews Redox Regulation in the Base Excision Repair Pathway: Old and New Players as Cancer Therapeutic Targets
Current Medicinal Chemistry