摘要
药用植物和蘑菇作为癌症治疗的一个有吸引力的天然化合物来源,一直吸引着世界。从古代起,它们就开始成为东方实践中的美食和民间医学。40多年来,世界已经见证了西方科学界对天然产品在抗癌方面的制药潜力的巨大兴趣。成功预防血管生成和癌症转移的植物和蘑菇属于某些植物,包括玫瑰花、芦荟、番荔枝、番莲、蘑菇、蘑菇和蘑菇、蘑菇、灵芝、灵芝、蘑菇和蘑菇。抗癌化合物作为自由基清除剂和活性氧诱导剂、有丝分裂纺锤形激酶抑制剂、抗有丝分裂、血管生成抑制剂、拓扑异构酶抑制剂、凋亡诱导剂,最终检测肿瘤侵袭、迁移和增殖。本综述更新和关注最近发现的药理学潜在的生物活性化合物,他们的抗肿瘤的潜在潜力,防止癌症转移和血管生成的潜在机制,以提高知识进一步研究开发无副作用的癌症疗法的实验证据在临床前和临床水平的研究小组,关于天然产品预防癌症转移无疑使其成为一个值得广泛关注的快速研究领域。
关键词: 血管生成、细胞凋亡、癌症、炎症细胞因子、转移、活性氧。
Current Drug Targets
Title:Natural Products as Anticancer Agents
Volume: 22 Issue: 11
关键词: 血管生成、细胞凋亡、癌症、炎症细胞因子、转移、活性氧。
摘要: Medicinal plants and mushrooms have always fascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, the world has witnessed the overwhelming interest of the western scientific fraternity in the pharmaceutical potential of natural products in combating cancer. The plants and mushrooms credited with success against angiogenesis and cancer metastasis belong to certain Plants, including Catharanthus roseus, Aloe Vera,Annona muricata,Curcuma longa, Withania somnifera, and Berberis and mushrooms such as Agaricus, Antrodia, Ganoderma, Grifolafrondosa, Hericiumerinaceus, Phellinuslinteus, and Trametesversicolor Coriolusversicolor. The anti-cancer compounds play a pivotal role as a free radical scavenger and reactive oxygen species inducer, mitotic spindle kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, apoptosis inducers, and eventually checking cancer invasion, migration and proliferation. The present review updates and focuses on the recent findings of the pharmacologically potential bioactive compounds, their anti-tumor potential, and underlying mechanism of preventing cancer metastasis and angiogenesis in order to raise knowledge for further investigations to develop cancer therapeutics with no adverse side effects The mounting experimental evidence at pre-clinical and clinical levels from various research groups across the globe, regarding prevention of cancer metastasis by natural products unarguably make it a fast-track research area worth mass attention.
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Cite this article as:
Natural Products as Anticancer Agents, Current Drug Targets 2021; 22 (11) . https://dx.doi.org/10.2174/1389450121999201230204526
DOI https://dx.doi.org/10.2174/1389450121999201230204526 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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