Abstract
Pathophysiologic conditions of neurodegenerative diseases are unquestionably related to protein misfolding. The accumulation of misfolded proteins into relatively ordered structures such as fibrillar intracellular and extracellular amyloids results in tissue lesions that lead to neuronal loss and brain damage. In these pathologies, the occurrence of protein aggregates suggests certain inefficient or insufficient cellular responses of those molecular chaperones that should properly assist the folding of the client proteins. In this regard, most experimental models for neurodegenerative diseases have demonstrated that the overexpression of molecular chaperones provides effective neuroprotection. A subset of these molecular chaperones corresponds to a group of proteins that exhibit peptidylprolyl isomerase enzymatic activity, the immunophilins. Most of the family members of the latter group were first described as being responsible for the immunosuppressive response or they were reported as members of the chaperone complex associated with HSP90 in steroid receptor oligomers. In this article, we review some aspects of the liaison between molecular chaperones and neurodegenerative diseases, in particular heat-shock proteins and immunophilins with demonstrated influence on the proper function of mitochondria. This article is intended to address a field that represents a yet critical unmet clinical need for the development of neuroprotective molecules focused on potentially novel molecular targets.
Keywords: Immunophilins, Neurodegeneration, HSP90, FKBP51, FKBP52, Cyclophilin A.
Current Drug Targets
Title:Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases
Volume: 22 Issue: 14
Author(s): Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*
Affiliation:
- Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires,Argentina
Keywords: Immunophilins, Neurodegeneration, HSP90, FKBP51, FKBP52, Cyclophilin A.
Abstract: Pathophysiologic conditions of neurodegenerative diseases are unquestionably related to protein misfolding. The accumulation of misfolded proteins into relatively ordered structures such as fibrillar intracellular and extracellular amyloids results in tissue lesions that lead to neuronal loss and brain damage. In these pathologies, the occurrence of protein aggregates suggests certain inefficient or insufficient cellular responses of those molecular chaperones that should properly assist the folding of the client proteins. In this regard, most experimental models for neurodegenerative diseases have demonstrated that the overexpression of molecular chaperones provides effective neuroprotection. A subset of these molecular chaperones corresponds to a group of proteins that exhibit peptidylprolyl isomerase enzymatic activity, the immunophilins. Most of the family members of the latter group were first described as being responsible for the immunosuppressive response or they were reported as members of the chaperone complex associated with HSP90 in steroid receptor oligomers. In this article, we review some aspects of the liaison between molecular chaperones and neurodegenerative diseases, in particular heat-shock proteins and immunophilins with demonstrated influence on the proper function of mitochondria. This article is intended to address a field that represents a yet critical unmet clinical need for the development of neuroprotective molecules focused on potentially novel molecular targets.
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Daneri-Becerra Cristina, Ciucci M. Sol , Mazaira Gisela and Galigniana D. Mario *, Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases, Current Drug Targets 2021; 22 (14) . https://dx.doi.org/10.2174/1389450121999201230204320
DOI https://dx.doi.org/10.2174/1389450121999201230204320 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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