摘要
目的:2019年12月初,中国武汉出现大批新型冠状病毒肺炎(SARS-CoV-2)患者,引起全球关注。在治疗期间,几乎没有任何药物对衰竭表现出希望之光,病毒学抑制失效。此外,许多患者都经历了适应症外使用或同情使用治疗以及抗逆转录病毒、抗寄生虫药物、抗炎化合物和康复期血浆的口服/非肠道途径。本研究旨在整理和分析瑞德西韦和羟氯喹的疗效,了解其在COVID-19患者治疗和管理中的药物配置。 方法:从PubMed、Crossref、Springer、Bentham Sciences、Google Scholar、DOAJ、ScienceDirect、MEDLINE检索相关文献,检索关键词为COVID-19、SARS- COV-2、瑞德西韦、羟氯喹。本文研究并编辑了适当的同行评审文章。数据使用ChemOffice 2016 (Chem- Draw Professional 2016)和Microsoft Office软件制作。 结果:本研究表明,10篇文献中有5篇发现瑞德西韦导致恢复时间缩短,其余5篇文献发现瑞德西韦无方差且有局限性。然而,12篇文章中有6篇报道羟氯喹可增加生存机会或缩短恢复时间,其余6篇报道羟氯喹无作用。 结论:有必要评估更多瑞德西韦和羟氯喹的药代动力学和随机对照试验(RCT)。应与羟氯喹和瑞德西韦进行不同组合的研究,以获得更好的结果。
关键词: COVID-19,瑞德西韦,羟氯喹,SARS-CoV-2,羟化氯喹,药代动力学
Current Drug Targets
Title:Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19
Volume: 22 Issue: 13
关键词: COVID-19,瑞德西韦,羟氯喹,SARS-CoV-2,羟化氯喹,药代动力学
摘要:
Objective: Early in December 2019, mass sufferers due to Novel Coronavirus Pneumonia (SARS-CoV-2) in Wuhan (China) roused worldwide concern. Hardly any drugs showed the light of hope concerning the depletion in the period of treatment, and virological suppression became ineffective. Furthermore, numerous sufferers have undergone off-label use or compassionate use treatments as well as antiretroviral, antiparasitic agents, anti-inflammatory compounds, and convalescent plasma in either oral/parenteral route. This study aims to compile and analyze the effectiveness of Remdesivir and Hydroxychloroquine and give an insight into their drug profile in the treatment and management of COVID-19 patients.
Methods: Relevant literature was searched from PubMed, Crossref, Springer, Bentham Sciences, Google Scholar, DOAJ, ScienceDirect, and MEDLINE by using keywords like COVID-19, SARS-- COV-2, Remdesivir, and Hydroxychloroquine. Appropriate peer-reviewed articles were studied and compiled for this review paper. The figures were prepared by using ChemOffice 2016 (Chem- Draw Professional 2016) and Microsoft Office.
Results: This study indicates that 5 out of 10 works of literature find that Remdesivir leads to a reduction in recovery time, and the remaining 5 pieces of literature found Remdesivir to have no variance and have limitations. However, 6 out of 12 articles presented an increased chance of survival or reduction in recovery time due to hydroxychloroquine, while the remaining 6 presented hydroxychloroquine having no effect.
Conclusion: There is a need to assess more pharmacokinetics and randomized controlled trials (RCT) for Remdesivir and Hydroxychloroquine. Studies should be conducted in different combinations along with Hydroxychloroquine and Remdesivir to obtain better results.
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Cite this article as:
Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19, Current Drug Targets 2021; 22 (13) . https://dx.doi.org/10.2174/1389450121999201228212842
DOI https://dx.doi.org/10.2174/1389450121999201228212842 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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