针对SARS-CoV-2的潜在治疗候选药物和靶点的筛选模型综述

Title:A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2

Volume: 22 Issue: 11

关键词: 冠状病毒，covid-19，筛查模型、SARS-冠状病毒、肠道、中东冠状病毒呼吸综合征(MERS-CoV)。

摘要: Coronaviruses are a group of known RNA virus which primarily infect the respiratory tract, and also neurological, enteric, and hepatic systems. Endemic outbreaks of Middle East Coronavirus Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) have been observed in recent decades. A new strain named the SARS CoV-2(- COVID-19) virus has now spread across the globe. SARS-CoV-2 is highly communicable and has culminated in a massive pandemic of COVID-19. Currently, no successful treatment is available. Therefore, an urgent need is there for new screening models that can aid in identifying the drugs with potential activity against COVID-19. The current review aims to discuss various in-silico, in- -vitro and in-vivo screening methods that can potentially be used to expedite the discovery of new active therapeutic candidates and vaccines, drug targets, and repurposing the commercially available drugs against COVID-19 for the effective management of the infection and thereby controlling this pandemic. Further, the current status of drugs and vaccines under clinical investigation has been summarized.

Cite this article as:

A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2, Current Drug Targets 2021; 22 (11) . https://dx.doi.org/10.2174/1389450121666201228122845