Abstract
Histone deacetylase inhibitors are nowadays considered as promising anti-cancer drugs, as they interfere with several key steps of tumor development and progression, both in vitro and in vivo. Less attention has been paid to their impact on cell junctions. Nevertheless, cell junctions are gatekeepers in the management of tissue homeostasis, and their aberrant expression and functioning is observed in all aspects of cancer biology. The present review provides a state of the art of the current knowledge concerning the effects of histone deacetylase inhibitors on cell junctions. Besides an updated theoretical basis, we also exemplify its actual relevance in cancer therapy.
Keywords: histone deacetylase inhibitor, adherens junction, tight junction, gap junction, (hemi)desmosome, focal adhesion
Current Drug Targets
Title: Histone Deacetylase Inhibitors as Potent Modulators of Cellular Contacts
Volume: 7 Issue: 6
Author(s): Mathieu Vinken, Papeleu Peggy, Rogiers Vera and Vanhaecke Tamara
Affiliation:
Keywords: histone deacetylase inhibitor, adherens junction, tight junction, gap junction, (hemi)desmosome, focal adhesion
Abstract: Histone deacetylase inhibitors are nowadays considered as promising anti-cancer drugs, as they interfere with several key steps of tumor development and progression, both in vitro and in vivo. Less attention has been paid to their impact on cell junctions. Nevertheless, cell junctions are gatekeepers in the management of tissue homeostasis, and their aberrant expression and functioning is observed in all aspects of cancer biology. The present review provides a state of the art of the current knowledge concerning the effects of histone deacetylase inhibitors on cell junctions. Besides an updated theoretical basis, we also exemplify its actual relevance in cancer therapy.
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Cite this article as:
Vinken Mathieu, Peggy Papeleu, Vera Rogiers and Tamara Vanhaecke, Histone Deacetylase Inhibitors as Potent Modulators of Cellular Contacts, Current Drug Targets 2006; 7 (6) . https://dx.doi.org/10.2174/138945006777435281
DOI https://dx.doi.org/10.2174/138945006777435281 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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