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Review Article

基于纳米技术的肝细胞癌靶向研究

卷 22, 期 7, 2021

发表于: 09 December, 2020

页: [779 - 792] 页: 14

弟呕挨: 10.2174/1389450121999201209194524

价格: $65

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摘要

肝细胞癌(HCC)是原发性肝癌，在世界范围内的多种癌症中发病率和死亡率都很高。大量化疗药物用于治疗，由于其有限的位点特异性药物靶向能力，其成功率有限。因此，需要开发新的方法来治疗HCC。随着纳米技术为基础的药物传递方法的进步，传统化疗的挑战不断减少。由脂质和高分子复合材料组成的纳米药物为肝细胞癌的治疗提供了一个更好的平台，并开辟了新的途径。许多纳米载体，如表面工程脂质体、纳米粒子、纳米管、胶束、量子点等，已被研究用于治疗HCC。这些纳米载体在临床上被认为是递送化疗药物的高效载体，具有较高的位点特异性和治疗效率。本文综述了利用各种配体受体特异性靶向策略的纳米载体系统在肝癌治疗和管理中的应用。此外，文章还包括了目前临床批准的用于肝癌治疗的药物治疗的信息，以及此类纳米药物批准的监管要求的更新。

关键词: 肝癌，化疗，纳米载体，配体，肿瘤靶向，量子点

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