摘要
2019冠状病毒病(COVID-19)是由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的高致病性、高传染性病毒性疾病,起源于中国中部湖北省武汉市,在世界范围内迅速传播。SARSCoV- 2的基因组序列与蝙蝠源的严重急性呼吸综合征样(如SARS)冠状病毒具有系统发育相关性;因此蝙蝠可能是主要的宿主。目前,没有临床获批的抗疫疫苗或抗病毒药物。然而,一些广谱抗病毒药物已经在临床研究中被评估用于治疗COVID-19,并使得患者病情得以改善。在这方面,正在研究其他疗法,如抗病毒药物、抗体、干细胞和血浆疗法。本文综述了COVID-19感染的发生、致病性和基因组结构。这项研究的主要重点是可能对SARS-CoV-2有效的治疗方法。
关键词: COVID-19,新型冠状病毒,治疗性,SARS-CoV-2,抗病毒,SARS-CoV-19。
Current Molecular Medicine
Title:Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future Perspective
Volume: 21 Issue: 7
关键词: COVID-19,新型冠状病毒,治疗性,SARS-CoV-2,抗病毒,SARS-CoV-19。
摘要: The coronavirus disease 19 (COVID-19) is a highly pathogenic and transmissible viral disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in the city of Wuhan, Hubei Province, Central China and spread quickly around the world. The genome sequence of SARSCoV- 2 is phylogenetically related to bat-derived severe acute respiratory syndrome-like (SARS-like) coronaviruses; therefore bats could be the possible primary reservoirs. At present, there are no clinically approved vaccines or specific antiviral drugs for COVID- 19. However, several broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical studies and resulted in the improvement of patients. In this regard, other therapies such as antiviral drugs, antibodies, stem cells and plasma therapy are being studied. In the current study, we reviewed the emergence, pathogenicity and the genome structure of COVID-19 infection. The main focus of this study is on the therapeutic approaches that may be effective against SARS-CoV-2.
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Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future Perspective, Current Molecular Medicine 2021; 21 (7) . https://dx.doi.org/10.2174/1566524020666201203170230
DOI https://dx.doi.org/10.2174/1566524020666201203170230 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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