摘要
在大多数腺上皮起源的癌症中,MUC蛋白作为预后和诊断标志物以及治疗干预的潜在靶标均具有重要意义。这些是位于若干组织和导管上皮内层的高分子量糖基化蛋白。粘蛋白属于可分泌或膜结合的大O-糖蛋白的异质类。糖基化,翻译后修饰影响生物物理,功能和生化特性,并为这些蛋白质提供结构复杂性。粘蛋白的异常表达和糖基化有助于许多癌症的存活和增殖,进而激活多种信号通路,例如NF-kB,ERα,HIF,MAPK,p53,c-Src,Wnt和JAK-STAT等。随后诱导癌细胞生长,增殖和转移。本综述主要证明了MUC糖蛋白的功能方面,以及其独特的信号传导机制以及异常糖基化在癌症进展和治疗中的作用。已经证明了MUC蛋白及其亚型在包括但不限于乳腺癌,结肠直肠癌,子宫内膜癌和宫颈癌,肺癌,原发性肝癌,胰腺癌,前列腺癌和卵巢癌的广泛癌症中的重要性。在定位上相同。在本综述中,还强调了与MUC蛋白相关的癌症治疗领域的几项专利。
关键词: 癌症,MUC蛋白,粘蛋白,生物标志物,化学疗法,诊断,预后。
Current Cancer Drug Targets
Title:MUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy
Volume: 21 Issue: 2
关键词: 癌症,MUC蛋白,粘蛋白,生物标志物,化学疗法,诊断,预后。
摘要: MUC proteins have great significance as prognostic and diagnostic markers as well as a potential target for therapeutic interventions in most cancers of glandular epithelial origin. These are high molecular weight glycosylated proteins located in the epithelial lining of several tissues and ducts. Mucins belong to a heterogeneous group of large O-glycoproteins that can be either secreted or membrane-bound. Glycosylation, a post-translational modification affects the biophysical, functional and biochemical properties and provides structural complexity for these proteins. Aberrant expression and glycosylation of mucins contribute to tumour survival and proliferation in many cancers, which in turn activates numerous signalling pathways such as NF-kB, ERα, HIF, MAPK, p53, c-Src, Wnt and JAK-STAT, etc. This subsequently induces cancer cell growth, proliferation and metastasis. The present review mainly demonstrates the functional aspects of MUC glycoproteins along with its unique signalling mechanism and role of aberrant glycosylation in cancer progression and therapeutics. The importance of MUC proteins and its subtypes in a wide spectrum of cancers including but not limited to breast cancer, colorectal cancer, endometrial and cervical cancer, lung cancer, primary liver cancer, pancreatic cancer, prostate cancer and ovarian cancer has been exemplified with significance in targeting the same. Several patents associated with the MUC proteins in the field of cancer therapy are also emphasized in the current review.
Export Options
About this article
Cite this article as:
MUC Glycoproteins: Potential Biomarkers and Molecular Targets for Cancer Therapy, Current Cancer Drug Targets 2021; 21 (2) . https://dx.doi.org/10.2174/1568009620666201116113334
DOI https://dx.doi.org/10.2174/1568009620666201116113334 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Innovative Cancer Drug Targets: A New Horizon in Oncology
Cancer remains one of the most challenging diseases, with its complexity and adaptability necessitating continuous research efforts into more effective and targeted therapeutic approaches. Recent years have witnessed significant progress in understanding the molecular and genetic basis of cancer, leading to the identification of novel drug targets. These include, but ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Human L1 Element: A Potential Biomarker in Cancer Prognosis, Current Status and Future Directions
Current Molecular Medicine Dehydroepiandrosterone and Its Derivatives: Potentially Novel Anti-Proliferative and Chemopreventive Agents
Current Pharmaceutical Design New Trends in Anti-Cancer Therapy: Combining Conventional Chemotherapeutics with Novel Immunomodulators
Current Medicinal Chemistry Survivin: Role in Normal Cells and in Pathological Conditions
Current Cancer Drug Targets Biotransformation of Terpenoids: A Green Alternative for Producing Molecules with Pharmacological Activity
Mini-Reviews in Organic Chemistry DNA Instability at Chromosomal Fragile Sites in Cancer
Current Genomics 2',6'-dihydroxy-4'-methoxy Dihydrochalcone Improves the Cognitive Impairment of Alzheimer's Disease: A Structure-activity Relationship Study
Current Topics in Medicinal Chemistry Anal Cancer: Focus on HIV-Positive Patients in the HAART Era
Current HIV Research Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target
Current Medicinal Chemistry Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance
Current Cancer Drug Targets Marine Peptides and Related Compounds in Clinical Trial+
Anti-Cancer Agents in Medicinal Chemistry Antecedents of Voluntary Surgical Sterilization Among Poor Women in Tamil Nadu: Urban vs. Rural Areas
Current Women`s Health Reviews Anticarcinogenic Effects of Capsaicin-Loaded Nanoparticles on In vitro Hepatocellular Carcinoma
Current Chemical Biology ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis
Current Pharmaceutical Design Immunity to Bacterial Infections
Current Immunology Reviews (Discontinued) A New Cutset-type Kernelled Possibilistic C-means Clustering Segmentation Algorithm Based on SLIC Super-pixels
Journal of Fuzzy Logic and Modeling in Engineering Expression and Purification of Tag-removed Human IL37 by Digestion on Beads in Escherichia coli
Protein & Peptide Letters Histone Deacetylase Inhibitors in Cancer Therapy: New Compounds and Clinical Update of Benzamide-Type Agents
Current Topics in Medicinal Chemistry The Pragmatism of Polyphenols and Flavonoids Application as Drugs, from an Academic Lab to a Pharmacy Shelf
Current Pharmaceutical Design Sydnone: Synthesis, Reactivity and Biological Activities
Current Medicinal Chemistry