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摘要
背景:表观遗传修饰模式被认为是血液恶性肿瘤的一个特征性特征。DNA甲基化调节剂的修饰在淋巴瘤和白血病中反复出现,因此不同的甲基化模式定义了不同类型的白血病。一般来说,表观遗传学的作用是不太了解的,大多数调查集中在遗传异常和细胞遗传学研究,以开发新的治疗血液疾病患者。最近,了解急性淋巴细胞白血病(ALL)的潜在机制,特别是表观遗传改变作为ALL发展的驱动力,开启了一个新的研究时代,以开发有前途的策略,超出现有的常规治疗。 目的:本综述将聚焦于更好地理解癌症发展和进展中的表观遗传学机制,重点是所有表观遗传学改变,包括DNA甲基化、组蛋白修饰和microRNA改变。其他将讨论的话题包括使用表观遗传改变作为一个有希望的治疗靶点,以开发新的,适合的方法对抗ALL。 结论:根据文献综述,ALL的白血病发生受到表观遗传修饰的广泛影响,特别是DNA超甲基化、组蛋白修饰和miRNA改变。
关键词: 表观遗传修饰,急性淋巴细胞白血病,DNA甲基化,组蛋白修饰,MicroRNA改变,治疗靶点
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